Main description:

This book reviews the current concepts in biofilm formation and its implications in human health and disease. The initial chapters introduce the mechanisms of biofilm formation and its composition. Subsequently, the chapters discuss the role of biofilm in acute and chronic infections. It also explores the pivotal role of both innate and adaptive immunity on the course of biofilm infection. In addition, the book elucidates the bacterial biofilm formation on implantable devices and the current approaches to its treatment and prevention. It analyzes the possible relationship between antimicrobial resistance and biofilm formation. Finally, the book also summarizes the current state-of-the-art therapeutic approaches for preventing and treating biofilms.

This book is a useful resource for researchers in the field of microbiology, clinical microbiology, and also medical practitioners.

Contents:

Chapter 1_Bacterial and other acute Infections. - Chapter 1.1. Introduction to Bacterial biofilm. - Chapter 1.2. Planktonic and Biofilm growing bacteria. - Chapter 1.3. Quorum sensing and biofilm . - Chapter 1.4. Infection Pathogenesis. -Chapter 2. Quorum sensing. -Chapter 2.1. Mechanism of quorum sensing in Gram positive and Gram negative bacteria. -Chapter 2.2. Quorum sensing molecules. -Chapter 2.3. Quorum sensing and virulence. -Chapter 2.4. Pharmacological perspective of quorum sensing. -Chapter 3. Bacteria and biofilms as natural inhabitants of our body. -Chapter 3.1. Oral Biofilms. -Chapter 3.2. Skin Microbiology. -Chapter 3.3. Commensal Biofilm Gut Flora. -Chapter 3.4. Other sites of Bacterial Biofilms in body.-Chapter 4. Role of Biofilms in acute and chronic infections. -Chapter 4.1. Biofilm in acute infection. -Chapter 4.2. Chronic Infections - Host response. -Chapter 4.3. Chronic Infections - Treatment failure. -Chapter 4.4. Chronic Infections Persistency. -Chapter 5. Role of biofilms in nosocomial diseases. -Chapter 5.1. Biofilm and Cystic Fibrosis. -Chapter 5.2 Biofilm and Chronic Wounds. -Chapter 5.3. Biofilm and Endophthalmitis. -Chapter 5.4. Biofilm and Keratitis. -Chapter 6.Immune response to biofilm. -Chapter 6.1. Immune evasion by biofilm. -Chapter 6.2. Skewing of immune response. -Chapter 6.3. Local immune response. -Chapter 6.4. Systemic immune response. -Chapter 7. Biofilm in medical appliances. -Chapter 7.1. Biofilm and Implants. -Chapter 7.2. Biofilm in Tissue Fillers. -Chapter 7.3. Biofilm in Otitis Media. -Chapter 7.4. Biofilm in Intravascular Catheter. -Chapter 8. Biofilm and antimicrobial resistance. -Chapter 8.1. Antibiotic resistance by biofilm. -Chapter 8.2. Mechanism of antibiotic resistance. -Chapter 8.3. Genetic basis of resistance- mobile genetic elements. -Chapter 8.4. Effects of antibiotic resistance. -Chapter 9. Inhibition of biofilm formation. -Chapter 9.1. Inhibition of quorum sensing and signalling pathways. -Chapter 9.2. Other interacting members in a bacterial biofilm. -Chapter 9.3. Natural antibiofilm compounds. -Chapter 9.4. Phytochemicals and biofilm. -Chapter 10. Novel and Future Treatment Strategies for Biofilm associated infections. -Chapter 10.1. Phytomedicine. -Chapter 10.2. New antimicrobials. -Chapter 10.3. Nanoparticles/ Nanomedicine. -Chapter 10.4. Latest antibiotics in pipeline and antibiotic adjuvants.