Main description:

While many other textbooks concentrate on simply one aspect of women’s health (i.e., sexual or reproductive, but not both), we offer the reader a single, comprehensive, multidisciplinary source that will detail all of the essential points relevant to any clinician involved in the care of women’s reproductive and sexual issues, as female sexuality, fertility, and reproduction are inextricably tied. Because clinicians who treat women in any of these areas often need to reference data in one of the other related fields, we anticipate that this book will significantly reduce the need to consult multiple sources, and thus allow for the more efficient practice of medicine.

Contents:

I. Reproduction

Anatomy and Physiology

1. Pre-implantation stages of human embryogenesis

• Brief description of pre-implantation development of fertilized ovum

• Implantation of fertilized ovum

• Changes of endometrium in pregnancy and early development of placenta including characterization of gene expression








• Hormonal support of early embryonic development

1^st Choice Author: Philip Iannaccone (Northwestern U, Chicago, IL)

Alternate: David Walterhouse (Northwestern U, Chicago, IL)

2. Control of sexual differentiation in utero

• Molecular and biological sexual differentiation of the brain








• Magnetic resonance imaging of the brain sexual differentiation








• Genital tract development in utero








• Sexual behavior, mood, and memory later in life as a result of sexual differentiation of brain

1^st Choice Author: Joe Simpson (Baylor College of Medicine, Houston, TX)

Alternate: Ieuan Hughes (U of Cambridge, Cambridge, UK)

3. Biology of the ovary

• Development of the ovary in utero and after birth








• Ovarian structure and function during the reproductive years








• Mechanisms of in vivo oocyte maturation








• Gene expression during oocyte maturation








• Developmental expression of estrogen and androgen receptors in the ovary








• The two-cell concept








• Ovarian steroidogenesis








• Ovarian peptides: secretion and action








• Ovarian changes during pregnancy








• Ovarian changes during menopause

1^st Choice Author: Gregory Erickson (UCSD, La Jolla, CA)

Alternate: KP McNatty (Victoria U f Wellington, New Zealand)

4. Female puberty

• Adrenarche








• Gonadarche








• Changes in gonadotropin secretion pattern during puberty








• Tanner stages of secondary sexual characteristics








• Establishment of menstrual cycle and ovulation








• Delayed puberty








• Precocious puberty

1^st Choice Author: Robert Rosenfield (Oregon Health & Science U, Portland,

OR)

Alternate: Walter Miller (UCSF, San Francisco, CA)

5. Control of the normal menstrual cycle

• Ontogeny and regulation of GnRH secretion in the hypothalamus and in the female reproductive organs, including role of genetics and life cycle of the GnRH neurons








• Pituitary gonadotropin secretion








• Feedback mechanisms of the hypothalamic-pituitary-ovarian axis








• Reproductive hormone changes during the normal menstrual cycle

1^st Choice Author: Robert Rebar (U of Cincinnati, Cincinnati, OH)

Alternate: Eli Adashi (Brown U, Providence, RI)

6. Physiologic effects of androgens in women

• Androgen secretion during the normal menstrual cycle








• Androgen actions on brain, and on sexual development








• Androgen actions on secondary sexual characteristics








• Androgen actions on other target tissues in women

1^st Choice Author: Susan Davis (Monash U, Australia)

Alternate: Glenn Braunstein (Cedars-Sinai Medical Center, Los Angeles, CA)

Pathophysiology, Investigation, and Treatment

7. Primary ovarian dysfunction and other congenital diseases

• Genetic and molecular disorders associated with primary ovarian

dysfunction and other congenital diseases

• Phenotypes of primary ovarian dysfunctions and other congenital

diseases

• Investigation of women presenting with primary ovarian dysfunction and

other congenital diseases

• Treatment of women presenting with primary ovarian dysfunction and other congenital diseases

1^st Choice Author: Robert Jaffe (UCSF, San Francisco, CA)

Alternate: Barbara Lippe (Genentech/UCLA, Los Angeles, CA)

8. Polycystic ovarian disease and other androgenic syndromes

• Causes of androgen-producing tumors, hyperthecosis, PCOD, and Cushing’s disease








• Genetic, molecular and morphological abnormalities associated with hyperandrogenic syndromes








• Clinical manifestations of hyperandrogenism in women, including evidence for premature pubarche








• Hormonal and metabolic abnormalities in women with hyperandrogenism








• Clinical investigation of women with hyperandrogenism








• Treatment of women with hyperandrogenism

1^st Choice Author: Andrea Dunaif (Northwestern U, Chicago, IL)

Alternate: John Nestler (Virginia Commonwealth U, Richmond, VA)

9. Excessive prolactin secretion and reproductive function

• Pathogenesis of excessive prolactin secretion in women








• Clinical manifestations of hyperprolactinemia in women








• Hormonal and metabolic abnormalities in women with








• hyperprolactinemia








• Clinical investigation of women with hyperprolactinemia








• Treatment of women with hyperprolactinemia








• Pregnancy in women with hyperprolacinemia

1^st Choice Author: Mark Molitch (Northwestern U, Chicago, IL)

Alternate: Fouad Kandeel (City of Hope National Medical Center, Duarte, CA)

10. Ovulatory dysfunction due to other endocrine diseases

• Ovulation dysfunction due to CNS-hypothalamic-pituitary dysfunction








• Ovulation dysfunction in patients with CNS-hypothalamic-pituitary mass lesions








• Ovulation dysfunction in patients with thyroid disease








• Ovulation dysfunction in patients with adrenal disease








• Ovulation dysfunction in patients with diabetes

1^st Choice Author: Michael Thomas (U of Cincinnati, Cincinnati, OH)

Alternate: C Fogel (U of North Carolina, Chapel Hill, NC)

11. Eating disorders, physical training and reproductive function

• Anorexia nervosa and reproductive function








• Bulimia and reproductive function








• Obesity and reproductive function








• Exercise and reproductive function

1^st Choice Author: Michelle Warren (Columbia U, New York, NY)

Alternate: Barbara Wolfe (Boston College, Boston, MA)

12. Premenstrual syndrome

• Pathogenesis of premenstrual syndrome








• Clinical manifestations of premenstrual syndrome








• Diagnostic workup of patients with premenstrual syndrome








• Treatment of premenstrual syndrome

1^st Choice Author: Robert Reid (Kingston General Hospital, Canada)

Alternate: Andrea J. Rapkin (UCLA, Los Angeles, CA)

13. Premature ovarian failure

• Pathogenesis of premature ovarian failure








• Genetic analysis of candidate genes in premature ovarian failure

• Genetics and molecular abnormalities associated with polyglandular endocrine failures








• Surgical menopause








• Diagnostic workup of patients with premature ovarian failure








• Treatment of women with premature ovarian failure








• Pregnancy in women with premature ovarian failure

1^st Choice Author: Barbara Lippe (Genentech, San Francisco, CA)

Alternate: Rogerio Lobo (Columbia U, New York, NY)

14. Endocrine disruptors: effect on female reproductive health

• Etiology of environmental toxins and hormone "imposters"








• Epidemiology of endocrine disruptors and associated reproductive function abnormalities








• Mechanisms of action of endocrine disruptors and hormone imposters on reproductive function, fertility, and female breast

1^st Choice Author: Jerrold Heindel (U of Texas, Austin, TX)

Alternate: J Toppari (U of Turku, Finland)

15. Hormonal changes in the menopausal transition and endocrine function of the postmenopausal ovary

• Definition of perimenopause








• Epidemiologic studies of perimenopause








• Changes in pituitary-ovarian axis with age
















• Hypothalamic GnRH input








• FSH & LH








• Gonadal steroids (estradiol, esterone, progesterone, androgens)








• Ovarian peptides









• Pathophysiology of menopausal symptoms








• Ovarian function in postmenopausal women








• Other endocrine changes in postmenopausal women








• Health consequences of menopause

1^st Choice Author: Henry Burger (Melbourne Prince Henry Institute, Australia)

Alternate: Katherine Rosewell (U of Kentucky, Lexington, KT)

Special Issues in Female Reproduction

16. Contraception in the 21^st century

• Current options for female contraception








• Different strategies for hormone-induced contraception

• Available preparations for hormonal suppression of ovulation

• Emergency contraceptives including humanized anti-hCG antibodies

1^st Choice Author: Daniel Mishell, Jr. (USC, Los Angeles, CA)

Alternate: Michael Kafrissen (U of North Carolina, Chapel Hill, NC)

17. Hormone replacement therapy (HRT)

• Physiology of menopause

• Pathophysiology of the vasomotor symptoms associated with menopause








• HRT for the menopausal symptoms








• HRT effects on breast cancer








• HRT effects on cardiovascular risks








• HRT effects on bone metabolism and fracture risks








• HRT effects on sexual function in the menopausal woman








• Counseling patients on HRT risks and benefits

1^st Choice Author: Robert Barbieri (Brigham & Women’s Hospital, Boston, MA)

Alternate: Gloria Bachmann (U of Medicine and Dentistry, New Brunswick, NJ)

18. Non-hormone treatment of menopausal symptoms

• Non-hormone therapies for menopause








• Effects of non-hormone therapies on vasomotor symptoms








• Effects of non-hormone therapies on cardiovascular risks

• Effects of non-hormone therapies on bone metabolism and fracture risk

• Effects of non-hormone therapies on sexual function in the menopausal woman

1^st Choice Author: Bruce Kessel (U of Hawaii, Honolulu, HI)

Alternate: Fredi Kronenberg (Columbia U, New York, NY)

19. Alopecia and hair loss in women

• Hair growth in women
















• Non-sexual hair








• Sexual hair









• Role of endocrine hormones in regulation of female hair growth
















• Estrogens








• Androgens








• Thyroid hormones








• Non-steroid hormones/growth factors









• Epidemiologic studies of hair growth related
















• Problems in women









• Excessive hair growth in women
















• Pathophysiology, investigations and treatment









• Alopecia
















• Pathophysiology, investigations and treatment

1^st Choice Author: Annaleen Vermeulen (U Hospital, Belgium)

Alternate: Rolf Hoffmann (Philipp U, Marburg, Germany)

20. Hormonal regulation of female breast and genital tract cancers

• Molecular and cellular regulation of hormones on breast cancer








• Molecular and cellular regulation of hormones on genital tract cancers

1^st Choice Author: Richard Santen (U of Virginia, Charlottesville, VA)

Alternate: Richard Blackwell (U of Alabama, Birmingham, AL)

21. Stem cell research in female reproduction

• Control of oocyte differentiation








• Embryonic stem cell differentiation to primordial germ cell








• Blastomeres as a source for stem cells








• Adult stem cell in the ovary and uterus








• Differentiation of other adult stem cell into reproductive tissue lineage








• Cellular reprogramming

• Genetic imprinting

• Nuclear transfer








• Tissue-engineered follicles

1^st Choice Author: Teresa Woodruff / Larry Jameson / Susan Park (Northwestern U, Chicago, IL)

Alternate: Antonin Bukovsky (U of Tennessee, TN)

II. Infertility

Anatomy and Physiology

22. Normal pregnancy and puerperium

• Function of placenta during pregnancy








• Hormone changes during pregnancy








• Maternal tissue changes during pregnancy








• Effect of maternal hormones on the developing fetus and after birth








• Hormonal changes during puerperium








• Common complications of pregnancy

1^st Choice Author: Victoria Snegovskikh (Yale U, New Haven, CT)

Alternate: John Challis (U of Toronto, Canada)

23. Physical and laboratory assessment of infertile women

• History and physical examination








• Assessment of basal body temperature and reproductive hormones in the infertile woman








• Other laboratory evaluations of couples with infertility

1^st Choice Author: Fouad Kandeel (City of Hope National Medical Center, Duarte, CA)

Alternate: R Isaksson (Helsinki U, Helsinki, Finland)

24. Imaging of the female genital tract

• Ultrasound








• MRI








• Salpingogram








• Other imaging modalities








• Structural abnormalities of the genital tract as a cause for female infertility

1^st Choice Author: JN Gutmann (Yale U, New Haven, CT)

Alternate: Willibrord Weijmar Schultz (University Hospital Groningen, Netherlands)

Pathophysiology, Investigation, and Treatment

25. Female genital tract infections

• Bacterial infections








• Fungal infections








• Viral infections








• Sexually transmitted diseases

1^st Choice Author: Gregor Reid (Lawson Health Research Institute, London, Canada)

Alternate: Suzanne Garland (The Royal Women’s Hospital of Women’s & Children’s Health, Victoria, Australia)

26. Infertility due to obstructive disorders

• Genital tract obstructive lesions








• Investigation








• Treatment of obstructive lesions of the female genital tract including tubal ligation reversal surgery








• Pregnancy in women with obstructive lesions

1^st Choice Author: Kevin Lederer (U of Connecticut Health Center, Farmington, CT)

Alternate: L Muzil / Salvatore Mancuso (U Cattolica del S. Cuore, Roma, Italy)

27. Infertility due to immunological factors

• Pathogenesis








• Immunological investigations including post-coital test








• Treatment strategies including use of immune isolation and desensitization strategies

1^st Choice Author: Harvey Kliman (Yale U, New Haven, CT)

Alternate: H.W. Gordon Baker (Royal Women’s Hospital, Australia)

28. Endometriosis

• Pathogenesis of endometriosis








• Mechanisms of infertility in women with endometriosis








• Investigations of patients with endometriosis








• Treatment strategies including hormonal and non-hormonal ablation therapy

1^st Choice Author: Linda Giudice, (UCSF, San Francisco, CA)

Alternate: Elizabeth Pritts (U of Wisconsin, Madison, WI)

29. Induction of ovulation

• Anti-estrogens








• Gonadotropins








• GnRH and its analogues (agonists and antagonists)








• Hypoglycemic agents








• Weight loss (obese patients)

1^st Choice Author: Michael Thomas (U of Cincinnati, Cincinnati, OH)

Alternate: Fouad Kandeel (City of Hope National Medical Center, Duarte, CA)

30. Induction of superovulation for in vitro fertilization and ovarian hyperstimulation syndrome

• Induction of superovulation for IVF








• Risk factors, incidence and manifestations of hyperstimulation syndrome








• Treatment of hyperstimulation syndrome








• Strategies to prevent hyperstimulation syndrome

1^st Choice Author: Stephen Franks (Hammersmith Hospital, London, UK)

Alternate: Suheil Muasher (Muasher Center for Fertility/George Washington University, Fairfax, VA)

31. Advances in assisted reproductive technologies

• Intrautrine insemination (IUI)








• In vitro fertilization (IVF)








• Intracytoplasmic sperm injection (ICSI)








• Micromanipulation of gametes








• Oocyte maturation in vitro








• Various sperm retrieval methods








• Pregnancy rates and complications

1^st Choice Author: Soon-Chye Ng (National U Hospital, Singapore)

Alternate: Herman Tournaye (Free U of Brussels, Brussels, Belgium)

Special Issues in Female Infertility

32. Fertility preservation for women with cancer

• Reproductive counseling of women with cancer desiring future fertility








• Ovarian shielding during radiotherapy








• Ovum and gamete preservation








• Ovarian retrieval, preservation, and retransplantation








• Use of adult and embryonic stem cells in restoring fertility of females surviving malignant diseases

1^st Choice Author: Kutluk Oktay (Cornell U, New York, NY)

Alternate: David Gershenson (U of Texas, Houston, TX)

33. Pregnancy in diabetic women

• Diagnosis of diabetes in pregnant women








• Metabolic changes during pregnancy








• Glycemic control during pregnancy








• Maternal and fetal complications associated with diabetes








• Later complications of diabetic pregnancy

1^st Choice Author: Oded Langer (Columbia U, New York, NY)

Alternate: Tim Cundy (University of Auckland, New Zealand)

34. Pregnancy in older women

• Changes in age of pregnancy in the industrial world








• Late pregnancy as a result of assisted reproductive technologies








• Acute and late complications associated with pregnancy of the older woman








• Psychological and social issues related to pregnancy of the older woman

1^st Choice Author: Zev Rosenwaks (Cornell U, New York, NY)

Alternate: Eyal Schiff (Sheba Medical Center, Israel)

35. Endocrine disorders in pregnancy

• Hyperprolactinemia








• Thyroid disease








• Adrenal disease








• Hypertension








• Insulin resistance and diabetes

1^st Choice Author: Mark Molitch, (U Pennsylvania, PA)

Alternate: Kenneth Leveno (U of Texas Southwestern Medical Center, Dallas, TX)

36. Offspring of in vitro fertilization

• Ethical and legal issues of pregnancy induced with donor sperm








• Ethical and legal issues related to donated ova and motherhood surrogacy








• Congenital abnormalities in offspring of IVF children








• Parenthood problems of IVF children








• Psychological impact on children born as a result of IVF

1^st Choice Author: Jennifer Kurinczuk (U of Leicester, Leicester, UK)

Alternate: Francoise Shenfield (U College Hospital, London, UK)

37. Social and psychological factors in female infertility

• Cultural issues associated with fertility and infertility








• Psychological factors in female Infertility








• Psychological counseling of the infertile couple








• Effects of adoption on female infertility

1^st Choice Author: Donna Stewart (U of Toronto, Ontario, Canada)

Alternate: Bruce Kessel (Harvard Medical School, Boston, MA)

III. Sexual Function

Anatomy and Physiology

38. Anatomic consideration of the female genital tract

• Anatomy of the female genital tract








• Neurological innervations and neural network of the female genital tract








• Vascular supply of the female genital tract

1^st Choice Author: Claire Yang (U of Washington, Seattle, WA)

Alternate: Helen O’Connell (U of Melbourne, Australia)

39. Normal female sexual cycle

• Classifications of the female sexual cycle








• Regulation of sexual desire in women








• Genital, somatic and emotional changes associated with sexual excitement and plateau in women








• Genital, somatic and emotional changes associated with orgasm and resolution in women during the sexual response cycle








• Effects of experience, hormonal activation, arousability, attention and sensory stimulation on the female sexual response








• Measurement of physiologic changes in the female genital tract during sexual arousal and orgasm

1^st Choice Author: Fouad Kandeel (City of Hope National Medical Center, Duarte, CA)

Alternate: Raymond Rosen (Robert Wood Johnson Medical School, New Brunswick, NJ)

40. Hormone regulation of female sexual function

• Molecular and cellular effects of reproductive hormones on the female genital tract








• Functional effects of reproductive hormones on the female genital tract








• Changes in female sexual response during the normal and abnormal menstrual cycle, pregnancy and puerperium

1^st Choice Author: Henry Burger (Jean Hailes Foundation, Australia)

Alternate: John Bancroft (The Kinsey Institute, Bloomington, IN)

41. MRI in studies of female sexual function

• fMRI studies of women during various stages of normal sexual response cycle








• MRI studies of the female genital tract during sexual intercourse








• fMRI and PET studies of brain activity during sexual arousal and orgasm in women

1^st Choice Author: Antonie Faix (Clinique Beausoleil, Montpellier, France)

Alternate: John DeLancey (U of Michigan, Ann Arbor, MI)

Pathophysiology, Investigation, and Treatment

42. Overview of women’s sexual dysfunction

• Summary chapter that provides broad, clear overview of upcoming topics in this section

1^st Choice Author: Rosemary Basson (U of British Columbia, Canada)

Alternate: Sue West (U of North Carolina, Chapel Hill, NC)

43. Disorders of sexual desire

• Hypoactive sexual desire and sexual aversion








• Hyperactive sexual desire and persistent arousal disorder








• Vaginal dryness








• Psychological, physical and functional evaluation of sexual arousal








• Treatment of sexual arousal disorders

1^st Choice Author: Sandra Leiblum (U of Medicine and Dentistry, Piscataway, NJ)

Alternate: Robert Segraves (Case Western Reserve U, Cleveland, OH)

44. Painful intercourse

• Structural abnormalities and pelvic trauma








• Genital tract infections








• Vaginismus








• Dyspareunia








• Vulvodynia








• Mixed sexual pain disorder

1^st Choice Author: Caroline Pukall (Queen’s U, Canada)

Alternate: Yitzchak Binik/Marie-Andree Lahai (McGill U, Canada)

45. Disorders of the female orgasm

• Primary anorgasmia








• Secondary anorgasmia








• Infrequent orgasmic response

1^st Choice Author: Cindy Meston (U of Texas, Austin, TX)

Alternate: Margaret Redelman (Sydney Centre for Sexual and Relationship Therapy, Australia)

46. Pharmacological agents and female sexual function

• Antihypertensives








• Psychotropics and centrally-acting drugs








• Antiestrogens and antiandrogens








• Contraceptives








• Drug therapy for female sexual dysfunction

1^st Choice Author: Jan Shifren (Massachusetts General Hospital, Boston, MA)

Alternate: Jonathan Schaffir (Ohio State U, Columbus, OH)

47. Substance abuse and female sexual function

• Alcoholism








• Oral, inhaled, and IV recreational drug use

1^st Choice Author: R. Karl H