Main description:

The tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials.

The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for scientists and medical doctors working and/or lecturing in the field of cancer research and immunology.

Contents:

Immune cells within tumor microenvironment.- Tumor-stroma interaction and cancer progression.- The role of tumor associated macrophages (TAMs) in tumor progression.- Dendritic cells dysfunction and tumor progression.- Myeloid-derived suppressor cells (MDSC) and tumor growth.- Tumor-infiltrating lymphocytes and their role in solid tumor progression.- Polymorphonuclear neutrophils and tumor: friend or foe?.- Cancer immunosurveillance and immunoediting.- Adoptive T cell immunotherapy - Perfecting self-defense.- Monoclonal antibodies to CTLA4 with focus on ipilimumab.