Main description:

This is the first book to comprehensively combine cutting edge information about the pathophysiology and novel therapeutic strategies in multiple sclerosis. The topics range from responses of the immune system to brain damage processes, as well as from molecular mechanisms to novel therapeutic strategies. The editors are internationally known for their basic and clinical research and first rate authors guarantee detailed and up-to-date coverage.

Contents:

IMMUNE REGULATION AND EFFECTOR DAMAGE MECHANISMS T cellular immune response -- from mouse to human (Wekerle) Tolerance towards myelin and its breakdown (Liblau) Antigen presentation and lymphocyte response in EAE/ MS. (Becher, Goebels) Transmigration of immune cells through the blood brain barrier (Ransohoff) Dysmyelination and remyelination in the central nervous system (Nave) Immune--mediated damage mechanisms in the brain (Owens) Axonal and neuronal pathology in MS (Trapp) Brain damage and its mechanisms (Perry) CLINICAL RESEARCH AND NOVEL THERAPEUTIC STRATEGIES New MRI strategies to understand the pathology of MS (Miller) Protection of oligodendrocytes in the inflamed brain (Gold) Repair in the brain via stem cell approaches in EAE/MS (Martino) Clinical MS (Tabira) Treatment effects in the MRI (Barkhof) Novel therapeutic strategies and the transfer into the clinics (Zipp)