Main description:

This book provides an overview on the organization and
function of the microtubule cytoskeleton, which is essential to many cellular
processes and profoundly linked to a range of human diseases.
Covering basic concepts as well as molecular details, the book discusses how
microtubules are nucleated and organized into ordered arrays, at different cell
cycle stages and in distinct cell types. In addition, the book highlights how
defects in the microtubule cytoskeleton are linked to diseases such as
neurodevelopmental disorders.

The book is intended for students, graduates and more
senior researchers in cell and developmental biology as well as for medical
doctors.

Contents:

Part 1. Organization of the microtubule cytoskeleton Microtubule nucleators.- Microtubule regulators.- Microtubule organizing centers. Part 2. Assembly, maintenance and function of microtubule-based organellesCentrioles/basal bodies.- Centrosomes.- Cilia. Part 3. The microtubule cytoskeleton and disease Microtubule-based.- Centrosome-based.- Ciliopathies.