Main description:

Can today's innovative practices and molecular tools tame this ancient disease?

One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035.

This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs.

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Contents:

Section 1: Towards Edward Jenner's Revenge: Developing an Effective Tuberculosis Vaccine A. Basic Immunology

1 Innate Immune Responses to Tuberculosis Jeffrey S. Schorey and Larry S. Schlesinger

2 Cytokines and Chemokines in Mycobacterium tuberculosis Infection Racquel Domingo-Gonzalez et al.

3 Regulation of Immunity to Tuberculosis Susanna Brighenti and Diane J. Ordway

4 The Memory Immune Response to Tuberculosis Joanna R. Kirman, Marcela I. Henao-Tamayo, and Else Marie Agger

5 Pathology of Tuberculosis: How the Pathology of Human Tuberculosis Informs and Directs Animal Models Randall J. Basaraba and Robert L. Hunter B. Animal Models

6 Animal Models of Tuberculosis: An Overview Ann Williams and Ian M. Orme

7 Mouse and Guinea Pig Models of Tuberculosis Ian M. Orme and Diane J. Ordway

8 Non-Human Primate Models of Tuberculosis Juliet C. Pena and Wen-Zhe Ho

9 Experimental Infection Models of Tuberculosis in Domestic Livestock Bryce M. Buddle, H. Martin Vordermeier, and R. Glyn Hewinson C. Vaccines

10 Clinical Testing of Tuberculosis Vaccine Candidates Mark Hatherill, Dereck Tait, and Helen McShane D. Human Immunology

11 Human Immunology of Tuberculosis Thomas J. Scriba, Anna K. Coussens, and Helen A. Fletcher

12 The Immune Interaction between HIV-1 Infection and Mycobacterium tuberculosis Elsa du Bruyn and Robert John Wilkinson

Section 2: Drug Discovery and Development: State of the Art and Future Directions

13 Preclinical Efficacy Testing of New Drug Candidates Eric L. Nuermberger

14 Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future DirectionsGregory M. Cook et al.

15 Targeting Phenotypically Tolerant Mycobacterium tuberculosis Ben Gold and Carl Nathan

Section 3: Biomarkers and Diagnostics

16 Tuberculosis Diagnostics: State of the Art and Future Directions Madhukar Pai, Mark P. Nicol, and Catharina C. Boehme

17 Latent Mycobacterium tuberculosis Infection and Interferon-Gamma Release Assays Madhukar Pai and Marcel Behr

18 Impact of the GeneXpert MTB/RIF Technology on Tuberculosis Control Wendy Susan Stevens et al.

Section 4: Host and Strain Diversity

19 The Role of Host Genetics (and Genomics) in Tuberculosis Vivek Naranbhai

20 The Evolutionary History, Demography, and Spread of the Mycobacterium tuberculosis Complex Maxime Barbier and Thierry Wirth

21 Impact of Genetic Diversity on the Biology of Mycobacerium tuberculosis Complex Strains Stefan Niemann et al.

22 Evolution of Mycobacterium tuberculosis: New Insights into Pathogenicity and Drug Resistance Eva C. Boritsch and Roland Brosch

Section 5: The Signature Problem of Tuberculosis Persistence

23 Acid-Fast Positive and Acid-Fast Negative Mycobacterium tuberculosis: The Koch Paradox Catherine Vilcheze and Laurent Kremer

24 Mycobacterial Biofilms: Revisiting Tuberculosis Bacilli in Extracellular Necrotizing Lesions Randall J. Basaraba and Anil K. Ojha

25 Killing Mycobacterium tuberculosis In Vitro: What Model Systems Can Teach Us Tracy L. Keiser and Georgiana E. Purdy

26 Epigenetic Phosphorylation Control of Mycobacterium tuberculosis Infection and ersistence Melissa Richard-Greenblatt and Yossef Av-Gay

27 DNA Replication in Mycobacterium tuberculosis Zanele Ditse, Meindert H. Lamers, and Digby F. Warner

28 The Sec Pathways and Exportomes of Mycobacterium tuberculosisBrittany K. Miller, Katelyn E. Zulauf, and Miriam Braunstein

29 The Role of ESX-1 in Mycobacterium tuberculosis Pathogenesis Ka-Wing Wong

30 The Minimal Unit of Infection: Mycobacterium tuberculosis in the Macrophage Brian C. VanderVen et al.

31 Metabolic Perspectives on Persistence Travis E. Hartman et al.

32 Phenotypic Heterogeneity in Mycobacterium tuberculosis Neeraj Dhar, John McKinney, and Giulia Manina

33 Mycobacterium tuberculosis in the Face of Host-Imposed Nutrient Limitation Michael Berney and Linda Berney-Meyer