Main description:

-Carboline and its derivatives have generated considerable interest in recent years for their versatile properties in chemistry and pharmacology. This is due to their ability to act as agonists to benzodiazepine receptors, hydroxy serotonin receptors, and intercalate into DNA, to inhibit CDK, Topisomerase, and monoamine oxidase enzymes. Their pharmacological properties include anxiolytic, hypnotic, anticonvulsant, antiviral, antiparasitic and antimicrobial attributes. This book provides a summary of methods for the synthesis of various natural products engineered with the diverse -carboline scaffold and their biological evaluation.

Contents:

Introduction. -carbolines as anticancer agents. -carbolines as antimalarial agents. -carbolines as antileishmanial agents. -carbolines as antifungal and antibacterial agents. -carbolines as anti-Inflammatory and analgesics agents. -carbolines for metabolic disorders. Neuroprotective -carbolines.