Main description:

This contributed volume provides a comprehensive assessment of the roles played by 5-HT2B receptors in humans. These receptors have been shown to play an important role is the cardiac, intestinal, and central nervous systems as well as in bone marrow formation and growth. In this book, expert researchers present their findings on molecular and physiological/pathological aspects of 5-HT2B receptors. The molecular section includes a discussion of the genetics of 5-HT2B receptors and impulse control. The physiological section covers their role in many biological systems including the nervous system, the heart, and the lungs.

Contents:

1 Gene structure, expression, and 5-HT2B receptor signaling

DEVELOPMENT AND GROWTH

2 Serotonin function during embryonic development: the 5-HT2B receptor contribution

3 Stem cells to decipher the physiological roles of 5-HT2B receptor signaling

4 The serotonergic system in hematopoiesis and hematopoietic disorders

5 The 5-HT2B receptor, the immune system and neuroinflammation.

6 5-HT2B Receptor on Macrophages: What for?

PERIPHERAL ACTIONS

7 Bone and 2B Serotonin receptor

8 Roles of 5-HT2B receptor in pain

9 5-HT2B receptor, the heart and blood vessels

10 5-HT2B receptor in Cardiopulmonary Disease

11 Serotonin and cardiac Valves Degeneration in dog

12 The discovery of 5-HT2B receptor pharmacology through the understanding of drug- induced valvulopathy

13 Serotonin and fibrosis

14 5-HT2B receptors in liver

15 Metabolic Regulation: Insulin secretion and action

BRAIN ACTIONS

16 Drugs of abuse affecting 5-HT2B receptors

17 The Role of 5-HT2B receptor on Aggression and Drugs of Abuse

18 Role of the serotonin 2B receptor in the reinforcing effects of psychostimulants

19 Serotonin 2B receptor interactions with dopamine network: implications for therapeutics in schizophrenia

20 A Role for the 5-HT2B receptor in the Neurobiology of Schizophrenia

21 5-HT2B receptors and antidepressants

22 Serotonin and the 5-HT2B receptor in amyotrophic lateral sclerosis