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Androgen Excess Disorders in Women

Series: Contemporary Endocrinology

by Ricardo Azziz

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Main description:

The field of androgen excess disorders has advanced substantially since the original publication of this book. The Androgen Excess Society (AES) was founded to bring together investigators in the field. A better understanding of the screening, progression, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has improved the clinical care and diagnostic accuracy of these patients. New criteria for the diagnosis of the polycystic ovary syndrome (PCOS) were proposed in Rotterdam, criteria that have resulted in controversy and, hopefully, initiation of new studies. The association of insulin resistance with PCOS has been strengthened, and the role of metformin in tre- ing the infertility of the PCOS has been validated. Risks for diabetes and, more cont- versially, cardiovascular disease in women with PCOS have received substantial investigation. Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance. These are but a few highlights of how the terrain has changed in a relatively brief period of time. In keeping with these advances, the title of this book has been revised to reflect the growing importance of PCOS as the most prevalent androgen excess disorder in women, and arguably, as the one that might have the most serious adverse consequences for general health. There are fewer chapters to provide a more focused elucidation of the area. Several chapters were penned by new (and young) authors who are conducting cutting-edge research in the field.

Contents:

I. Introduction

A Brief History of Androgen Excess
Ricardo Azziz

II. Physiology of Androgens

Ovarian and Adrenal Androgen Biosynthesis and Metabolis
Walter L. Miller, David H. Geller, and Mitchell Rosen

Androgens Throughout the Life of Women
C. Richard Parker, Jr.

Physiologic Effects of Androgens in Women
T. Keta Hodgson and Glenn D. Braunstein

Androgen Measurements: Methods, Interpretation and Limitations
Frank Z. Stanczyk

III. Pathophysiology of Androgen Excess

Androgen-Secreting Adrenal and Ovarian Neoplasms
Michel Pugeat, Gerald Raverot, Ingrid Plotton, Aude Brac de la Perriere, Pascale Mirakian, Henri Dechaud, Nicole Berger, and Jean Louis Peix

Cushing's Syndrome Acromegaly and Androgen Excess
Anne-Celine REYSS, Didier Dewailly

The Non Classic Adrenal Hyperplasias
Didier Dewailly and Ricardo Azzizb

Pregnancy-Related Androgen Excess
Howard D. McClamrock

Drug-Induced Hyperandrogenism
Christine Cortet-Rudelli and Didier Dewailly

The Severe Insulin Resistant Hyperandrogenic Syndromes
David E. Moller, Antonio Vidal-Puig, and Ricardo Azziz

Idiopathic Hirsutism
Enrico Carmina

Definition and Epidemiology of the Polycystic Ovary Syndrome
Ricardo Azziz

Clinical Features of PCOS
W. Futterweit, E. Diamanti-Kandarakis, and Ricardo Azziz

Biochemical Features of the Polycystic Ovary Syndrome
Adam Balen

Ovarian Histology, Morphology and Ultrasonography in PCOS
Sophie Jonard, Yann Robert, Yves Ardaens, and Didier Dewailly

Hypothalamic-Pituitary-Gonadotropic Dysfunction in PCOS
R. Jeffrey Chang and Rinku V. Mehta

Ovarian Steroidogenic Abnormalities in PCOS
Denis A. Magoffin

Hypothalamic-Pituitary Adrenal Dysfunction in Polycystic Ovary Syndrome
Bulent O.Yildiz, Enrico Carmina, and Ricardo Azziz

The Genetic Basis of Polycystic Ovary Syndrome
Mark O. Goodarzi

Pediatric Hyperandrogenism
Kathleen M. Hoeger

Environmental Factors in the Polycystic Ovary Syndrome
Marie-France Hivert and Jean-Patrice Baillargeon

Animal Models and Fetal Programming of PCOS
David H. Abbott, Daniel A. Dumesic, Jon E. Levine, Andrea Dunaif, and Vasantha Padmanabhan

Insulin Resistance and Hyperinsulinism in PCOS
Paulina A. Essah and John E. Nestler

The Endocrine Impact of Obesity and Body Habitus in PCOS
Pasquali Renato and Gambineri Alessandra

Molecular Mechanisms of Insulin Resistance in PCOS
Theodore P. Ciaraldi

Menstrual Dysfunction and Endometrial Neoplasia
Abdulkadir Wagley and Paul Hardiman

Beta Cell Dysfunction, Glucose Intolerance, and Diabetes in PCOS
David A. Ehrmann

Hypertension, and Cardiovascular and Lipoprotein Abnormalities
Francesco Orio and Stefano Palomba

Reproductive and Obstetrical Consequences of Polycystic Ovary Syndrome
Mary C. Johnson and Richard S. Legro

Psychosocial and Quality-of-Life Consequences of Androgen Excess
Onno E. Janssen, Susanne Hahn, and Sigrid Elsenbruch

Overview of Long-Term Morbidity and Economic Cost of PCOS
Ricardo Azziz

IV. Evaluation and Treatment of Androgen Excess

Clinical and Hormonal Evaluation of Androgen Excess
Ricardo Azziz

Ovarian Suppression and Treatment of Hirsutism
Paolo Moghetti

Polycystic Ovary Syndrome and Ovulation Induction
Bulent O. Yildiz and Ricardo Azziz

In Vitro Fertilization for Polycystic Ovary Syndrome
Hanadi Ba-Akdah, Ezgi Demirtas, Hananel Holzer, William Buckett, and Seang Lin Tan

The Surgical Management of Polycystic Ovary Syndrome
Adam Balen

Use of Insulin Sensit

PRODUCT DETAILS

ISBN-13: 9781588296634
Publisher: Springer (Humana Press Inc.)
Publication date: September, 2006
Pages: 488
Weight: 1100g
Availability: Available
Subcategories: Endocrinology, Obstetrics and Gynaecology

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