Main description:

This volume looks into the need for a variety of experimental models for research on traumatic brain injury (TBI) and peripheral nervous system. It also describes a number of experimental models, such as mechanical devices, that have been developed to model neurotrauma in animal experiments. The overall aim of this book is to explore the variety of models and how they are used in current research. The chapters in this book are organized in four sections and talk about animal models for TBI; animal models for spinal cord or nerve injury; and translational aspects, secondary injuries, in vitro studies, and evaluation of large data sets. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and comprehensive, Animal Models of Neurotrauma is a valuable resource for researchers interested in expanding their knowledge and research in this developing field.

Contents:

Series Preface...Preface...Table of Contents...Contributing Authors....
Part I Animal Models for Traumatic Brain Injury
1. The Fluid Percussion Injury Rodent Model in Preclinical Research on Traumatic Brain InjuryFredrik Clausen, Lars Hillered, and Niklas Marklund
2. Focal and Restricted Traumatic Injury Models in the Rodent Brain-Limitations, Possibilities, and ChallengesJesper Mogensen and Hana Mala
3. A Model for Research on Penetrating Traumatic Brain InjuriesJohan Davidsson and Marten Risling
4. A Sagittal Plane Rotational Injury Rodent Model for Research on Traumatic Brain InjuriesJohan Davidsson and Marten Risling
5. Experimental Models of Blast-Induced NeurotraumaPamela Boon Li Pun and Jia Lu
6. Utilization of Shock Tubes in Blast Injury ResearchIbolja Cernak
7. Introduction to Blast in the Context of Blast Induced TBIMat Philippens and Simon Ouellet
8. The Clemedson Blast TubeJohan Davidsson, Ulf Arborelius, Lars-Gunnar Ohlsson, Lizan Kawa, Kian Chye NG, Jia Lu, and Marten Risling
Part II Animal Models for Spinal Cord or Nerve Injury
9. Traumatic Peripheral Nerve Injuries - Experimental Models for Repair and ReconstructionLars B. Dahlin, Lena Stenberg, Ulrica Englund Johansson, and Fredrik Johansson
10. CNS Regeneration in Nerve Grafts - Practical Aspects of Complete Thoracic Spinal Cord Injury in RodentsArvid Frostell, Eric Peter Thelin, Per Mattsson, and Mikael Svensson
11. Experimental Nerve Plexus Root Avulsion and Spinal Cord ImplantationThomas Carlstedt and Marten Risling
12. Surgical Replantation of Avulsed Lumbosacral Ventral Roots and Urodynamic Studies in a Rhesus Macaque (Macaca mulatta) Model of Cauda Equina/Conus Medullaris Injury and RepairJaime H. Nieto, Huiyi H. Chang, Marcus Ohlsson, Una Lee, J. Pablo Villablanca, Kari L. Christe, and Leif A. Havton
Part III Translational Aspects, Secondary Injuries, In Vitro Studies or Evaluation of Large Data Sets
13. Secondary Insults in Experimental Traumatic Brain Injury - The Addition of HypoxiaCaroline Lindblad and Eric P. Thelin
14. A Translational Model of Traumatic Brain Injury: Sheep Impact Acceleration Robert Vink
15. In Vitro Trauma - Description of a Cavitation Inducing Injury ModelMattias. K. Skoeld and Anders Sonden
16. Clinically Relevant Outcome Measures for Experimental Traumatic Brain Injury (TBI) StudiesDenes V. Agoston, Jesse McCullogh, Roxanne Aniceto, Alaa Kamnaksh, David K. Wright, and Sandy R. Shultz
Part IV Conclusion
17. Concluding RemarksJohan Davidsson and Marten Risling