Main description:

The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics.

This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used to assess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.

Contents:

1. LC-MS Analysis of Serum and Plasma to Identify Circulating Biomarkers of SARS-CoV-2 Infection2. Mass Spectrometry Analyses Combined with Machine Learning to Identify Robust Biomarkers for COVID-19 Disease3. Selective Reaction Monitoring Mass Spectrometry Methods for Establishing a Panel of COVID-19 Biomarkers4. Chip-Based Assays for Multiplexed Analysis of SARS-CoV-2 Viral Infection5. Screening of Metabolic Profiles of Serum Metabolites in COVID-19 Patients6. Proteomic Techniques in Models of SARS-CoV-2 Infection7. Multiplex Immunoassay Approaches to Study the Cytokine Storm Effect8. Proteomic Methods for the Study of Organ Failure Associated with Severe COVID-19 Disease Courses9. Screening of Natural Products for COVID-19 Treatment using Multiplex Biomarker Readouts10. Multiplex Lateral Flow Antigen and Antibody Tests for Diagnosis and Surveillance of COVID-19 Disease11. Genomic Surveillance Techniques to Monitor SARS-CoV-2 Variants of Concern12. Multiplex Quantitative PCR Approaches for Diagnosis and Tracking of SARS-CoV-2 Variants13. Lipidomic Analysis of Fatty Acids as Potential New Biomarkers and Targets for Improved Treatment of COVID-19 Disease14. Multiplex Omic Methods for Screening and Triaging COVID-19 Patients According to Disease Severity15. Point-of-Care Techniques to Establish Risk of COVID-19 Disease Outcomes16. Multiplex Vaccination Approaches for Keeping Pace with Emerging SARS-CoV-2 Variants of Concern17. The Combined use of Artificial Intelligence and Circulating Molecular Profiles to Identify Prognostic Markers of COVID-19 Disease