Main description:

Collagens have a long history in both evolutionary and biotechnological research and continue to offer both challenges and exciting opportunities in regenerative medicine as nature's biomaterial of choice. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third Edition provides current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of these proteins can result in altered signaling properties of the original extracellular matrix (ECM). Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions with ties to endocrine function, and how this knowledge may be used to modulate various pathologies, including fibrotic disease.

This new edition has been expanded and revised to incorporate recent research advances, and dive into the powerful science of ECM and collagens. Several new chapters explore a range of chronic diseases in which the ECM and collagens, laminin and elastin are central players in disease modulation, including new chapters on lung, skin, and intestinal disease, as well cancers. The new edition also considers emerging analytical technologies that can detect biomarkers of ECM degradation, with discussion of protein quantification and detecting aging of collagens. Further chapters highlight how collagen biomarkers are used in clinical research to support drug development, as well as in precision medicine.

Contents:

1. Type I Collagen 2. Type II Collagen 3. Type III Collagen 4. Type IV Collagen 5. Type V Collagen 6. Type VI Collagen 7. Type VII Collagen 8. Type VIII Collagen 9. Type IX Collagen 10. Type X Collagen 11. Type XI Collagen 12. Type XII Collagen 13. Type XIII Collagen 14. Type XIV Collagen 15. Type XV Collagen 16. Type XVI Collagen 17. Type XVII Collagen 18. Type XVIII Collagen 19. Type XIX Collagen 20. Type XX Collagen 21. Type XXI Collagen 22. Type XXII Collagen 23. Type XXIII Collagen 24. Type XXIV 25. Type XXV Collagen 26. Type XXVI Collagen 27. Type XXVII Collagen 28. Type XXVIII Collagen 29. Laminins 30. Elastin 31. The collagen Chaperones 32. Collagen diseases 33. The Signals of the extracellular matrix 34. The roles of collagens in cancer and fibrosis 35. Use of extracellular matrix biomarkers in clinical research 36. Common confounders when evaluating noninvasive protein biomarkers 37. ECM and endotypes 38. The new collagen family 39. Collagen receptors 40. Dermatitis and skin diseases 41. The basements membrane quantification of respiratory diseases 42. The fibrosis and collagens of IBD 43. ECM biomarkers in population-based studies (PERF) 44. The collagen biomarkers of chronic diseases 45. One protein a 1000 neoepitopes - understanding of the epitope 46. Aging - the most important collagen neo-epitope? 47. Fibronectin