Main description:

An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potentially active organometallic drugs against incurable diseases, as well as in such areas as catalysis, energy, analytical chemistry, and imaging. The renowned editor, who established the term "bioorganometallics", and his international team of experts have put together a valuable resource for researchers in organometallic, inorganic, medicinal, and biochemistry.

Contents:

Preface PART I: Medicinal Chemistry ORGANOMETALLIC COMPLEXES AS ENZYME INHIBITORS: A CONCEPTUAL OVERVIEW Introduction Organometallic Compounds as Inert Structural Scaffolds for Enzyme Inhibition Organometallic Compounds Targeting Specific Protein Residues The Bioisosteric Substitution Novel Mechanisms of Enzyme Inhibition with Organometallic Compounds Organometallic Compounds as Cargo Delivers of Enzyme Inhibitors Organometallic Enzyme Inhibitors for Theranostic Purposes Conclusion THE BIOLOGICAL TARGET POTENTIAL OF ORGANOMETALLIC STEROIDS Introductory Note on Nuclear Receptors Steroids and Organometallics: An Overview of the Transitional Period from the Use of Organometallics in Synthesis to the Emergence of Bioorganometallics Epilog CHIRALITY IN ORGANOMETALLIC ANTICANCER COMPLEXES Introduction Chirality in Arene Complexes CIP System for the Nomenclature of Chiral-at-Metal Arene Complexes Chiral Organometallic Complexes as Anticancer Agents Half-Sandwich Complexes with Chiral Metal Centers Conclusions GOLD ORGANOMETALLICS WITH BIOLOGICAL PROPERTIES Introduction: The Use of Gold in Medicine Anticancer Gold Organmetallics and Proposed Biological Targets Conclusions and Perspectives ON THE MOLECULAR MECHANISMS OF THE ANTIMALARIAL ACTION OF FERROQUINE History and Development Mechanism(s) of Action 4-Aminoquinoline Antimalarials Mechanism(s) of Action of Ferroquine as an Antimalarial Conclusion METAL CARBONYL PRODRUGS: CO DELIVERY AND BEYOND Introducing CO in Biology Therapeutic Delivery of CO Biological and Therapeutic Results Obtained with the Early-Stage CORMs Beyond the Early-Stage CORMs: Strategies for Finding New Candidates Intracellular Detection of CORMs, Mechanistic Studies, and Other Unanswered Questions Designing Pharmacologically Useful, Drug-like CORMs Final Remarks and Perspectives DINITROSYL IRON COMPLEXES WITH NATURAL THIOL-CONTAINING LIGANDS: PHYSICOCHEMISTRY, BIOLOGY, AND MEDICINE Introduction The History of Detection and Identification of DNIC with Thiol-Containing Ligands in Microorganisms and Animal Tissues Physicochemistry of DNIC with Natural Thiol-Containing Ligands Biological Effects of DNIC with Thiol-Containing Ligands DNIC with Thiol-Containing Ligands as a Basis in the Design of Drugs with a Broad Range of Therapeutic Activities PART II: Metalloproteins, Catalysis, and Energy Production THE BIOORGANOMETALLIC CHEMISTRY OF HYDROGENASE Introduction Structure and Function Natural Biosynthesis and Synthetic Analogs of the Active Sites Comments and Conclusion BIO-ORGANOMETALLIC SYSTEMS FOR THE HYDROGEN ECONOMY: ENGINEERING OF ELECTRODE MATERIALS AND LIGHT-DRIVEN DEVICES Introduction Electrode Materials for Hydrogen Evolution and Uptake Light-Driven Systems for Hydrogen Evolution Artificial Photosynthetic Systems Summary and Conclusions ARTIFICIAL METALLOENZYMES CONTAINING AN ORGANOMETALLIC ACTIVE SITE Introduction Dative Anchoring Supramolecular Anchoring Covalent Anchoring Mixed Anchoring Modes Peptide Scaffolds Summary and Outlook PART III: Bioanalysis ORGANOMETALLIC BIOPROBES FOR CELLULAR IMAGING Introduction Luminescence Vibrational Spectroscopy Miscellaenous Conclusions Index