The marriage between synthetic biology and the traditional strengths of the pharmaceutical industry offers the potential of customized molecules with significantly higher binding to hitherto undruggable proteins. Systems biology and bioinformatics will be essential for distilling the vast amounts of gene, protein, and metabolite data that have been collected in recent years into a form that can enable drug discovery by identifying new targets and therapeutic mechanisms, as well as serving as an information conduit to synthetic biology. This book educates readers about this new paradigm of drug discovery.
The Modern History of the Drug Discovery Enterprise. The Anatomy of a Good Drug. The Wonders that are Natural. The Ingredients of Biosynthetic Engineering. Strain Engineering. Systems Biology: Making Sense of Complex Phenomena. The BioPharm. Case Studies.