Main description:

Bipolar disorder is a common, complex and costly mental health disorder, which sits at the heart of the practice of clinical psychiatry.Effective treatments (pharmacological, psychological and brain stimulation based) have all been discovered serendipitously.

With the huge advances in basic neuroscience the way is now clear for novel treatments to be developed based on brain science. This book reviews these possibilities.

Contents:

Preface.- The Neurobiology of Bipolar Disorder.- Pre-clinical studies and Animal Models.- Genetics in Bipolar.- Mitochondrial modulators for bipolar disorder: A paradigm for drug development.- Intracellular Signaling Cascades.- Circadian Rhythms and Sleep.- Neuroendocrine System in Bipolar.- Neuroanatomic and Functional Neuroimaging Findings.- Structural and Functional Aspects of Neuroprogression in BD.- Inflammation as a Mechanism of Neuroprogression.- Neurocognition in Bipolar.- The kindling/sensitization model and Early Life Stress.- Early Life Stress in Bipolar.- New pharmacological Interventions.