Published November, 2010
By Kenneth Hensley and Robert A. Floyd
Publisher: Springer (Humana Press Inc.)
Series: Methods in Pharmacology and Toxicology
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Availability: Available

Methods in Biological Oxidative Stress is practical in scope, providing the details of up-to-date techniques for measuring oxidative stress and detecting oxidizing agents both in vitro and in vivo.

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Published November, 2010
By Evelyn Tiffany-Castiglioni
Publisher: Springer (Humana Press Inc.)
Series: Methods in Pharmacology and Toxicology
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Availability: Available

Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing.

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Published November, 2010
By Anatoli Lopatin and Colin G. Nichols
Publisher: Springer (Humana Press Inc.)
Series: Methods in Pharmacology and Toxicology
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Availability: Available

The introduction of patch clamp technology by Erwin Neher and Bert Sakmann about 20 years ago led to the realization of the great variety of novel ion channel species, and the subsequent revolution in cl- ing has revealed an even greater diversity of the underlying molecular entities.

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Published November, 2010
By Nadine Cohen
Publisher: Springer (Humana Press Inc.)
Series: Methods in Pharmacology and Toxicology
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Availability: Available

The book presents an industry perspective on the implementation of PGx in research and development, in drug discovery, and in clinical trials, including rec- mendations for a systematic approach for assessing the feasibility and added value of PGx studies in clinical trials.

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Published November, 2010
By Zhengyin Yan, Gary Caldwell and Gary W. Caldwell
Publisher: Springer (Humana Press Inc.)
Series: Methods in Pharmacology and Toxicology
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Availability: Available

Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development.

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Published November, 2010
By Lawrence H. Lash
Publisher: Springer (Humana Press Inc.)
Series: Methods in Pharmacology and Toxicology
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Availability: Available

Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

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Published September, 2008
By Nadine Cohen
Publisher: Springer (Humana Press Inc.)
Series: Methods in Pharmacology and Toxicology
Rating:
Availability: Available

The book presents an industry perspective on the implementation of PGx in research and development, in drug discovery, and in clinical trials, including rec- mendations for a systematic approach for assessing the feasibility and added value of PGx studies in clinical trials.

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Published March, 2008
By Wang Feng and Feng Wang
Publisher: Springer (Humana Press Inc.)
Series: Methods in Pharmacology and Toxicology
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Availability: Available

In this book, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies.

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Published April, 2007
By Robert V. House and Jacques Descotes
Publisher: Springer (Humana Press Inc.)
Series: Methods in Pharmacology and Toxicology
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Availability: Available

This comprehensive book explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. It includes a basic study of cytokines and details the effects of cytokines on the immune system and in treating cancer.

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