Published January, 2012
By Henry M. Staines and Sanjeev Krishna
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
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Availability: Available

Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs.

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Published September, 2011
By Mark von Itzstein and Mark Itzstein
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
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Availability: Available

Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented.

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Published January, 2011
By Christoph C. Zielinski, Maria Sibilia, Thomas Grunt, Rupert Bartsch, Thomas W. Grunt and Christoph Zielinski
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
Rating:
Availability: Available

Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors.

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Published November, 2010
By Kenneth C. Anderson, Paul G. Richardson, Irene Ghobrial and Irene M. Ghobrial
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
Rating: 1.00
Availability: Available

Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells.

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Published September, 2010
By Phil Skolnick
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
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Both metabotropic and ionotropic glutamate receptors present attractive "druggable" targets in treating disorders of the central nervous system.

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Published May, 2010
By Yuti Chernajovsky and Paul D. Robbins
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
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Availability: Available

In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells.

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Published September, 2009
By Francesco M. Veronese and Mary J. Bossard
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
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Availability: Available

Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed.

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Published April, 2009
By Maryann Foote, Graham Molineux and Steven G. Elliott
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
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Availability: Available

The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators.

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Published December, 2007
By Jeffrey M. Weinberg
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
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Availability: Available

This volume provides an in-depth overview of the current state of psoriasis and its management. It reviews the clinical manifestations of psoriasis as well as psoriatic arthritis and emphasizes the evolving paradigm of therapy. Coverage includes topical and ultraviolet therapies as well as traditional systemic therapy.

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Published December, 2007
By William R. Miller, Aman U. Buzdar, J Michael Dixon, J. M. Dixon, B.J.A. Furr, R. Paridaens, Alasdair Brodie, A. Buzdar, P. E. Lonning, W.R. Miller, E.R. Simpson, A.E. Wakeling, Robert Paridaens, Angela Brodie, Aman Buzdar, Per Eystein Lonning, Evan R. Simpson and Alan E. Wakeling
Publisher: Springer (Birkhauser Verlag AG)
Series: Milestones in Drug Therapy
Rating: 1.00
Availability: Available

This book provides the first comprehensive overview on the different aromatase inhibitors. Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not very potent and lacked specificity.

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