Main description:

This first book to focus on the importance of epigenetics during both early and late stages of cancer development presents both researchers and clinicians with an invaluable overview by way of top contributions from leading scientists around the world. Introductory sections make this ideal reading for researchers just entering the field, while both fundamental epigenetic mechanisms along with their clinical and therapeutic applications are equally covered.

Contents:

BASIC EPIGENETICS DNA methylation Methyl-binding proteins Histone modifications and gene regulation CANCER EPIGENETICS Cancer Epigenetics Modeling cancer epigenetics Genomic imprinting and cancer DNA hypomethylation in cancer cells Causes of epigenetic alterations in cancer Methods in Cancer Epigenetics CLINICAL EPIGENETICS Diagnostic utility of DNA methylation in cancer Epigenetic therapy AN ORGAN SYSTEMS APPROACH Breast cancer Lung cancer Colon cancer Head and Neck/esophagus Kidney and Bladder cancer Hematologic malignancies Pancreas Ovarian/endometrial cancer Brain Tumors