Main description:

This book presents the latest findings in the field of cardiac mechanobiology in health and disease.

Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells.

This volume of the series Cardiac and Vascular Biology complements the volume Vascular Mechanobiology in Physiology and Disease (volume 8) published in this series. The book is aimed at clinicians as well as researchers in cardiovascular biology, bioengineering and biophysics, and also represents an educational resource for young researchers and students in these fields.

Contents:

Foreword

1. Cardiac mechanoperception and mechanotransduction - Mechanisms of stretch sensing in cardiomyocytes and implications for cardiomyopathy. Authors: Matthias Eden*, Lucia Kilian, Derk Frank and Norbert Frey

2. Mechanotransduction in heart development. Authors: Alexandra E. Giovou, Vincent M. Christoffels*

3. Mechanobiology of cardiac growth in health and disease. Authors: Gloria Garoffolo and Maurizio Pesce*

4. The role of mechanosensitive signaling cascades in repair and fibrotic remodeling of the infarcted heart. Authors: Claudio Humeres, Harikrishnan Venugopal, and Nikolaos G Frangogiannis*

5. Mechanobiology of cardiac fibroblasts in cardiac remodelling. Authors: Luke R. Perreault* and Lauren D. Black III

6. Mechanobiology of cardiac remodelling in cardiomyopathy. Authors: Thomas Randall and Elisabeth Ehler*

7. Biophysical Stretch Induced Differentiation and Maturation of Induced Pluripotent Stem Cell-derived Cardiomyocytes. Authors: Jiabin Qin, Alain van Mil, and Joost P. G. Sluijter*

8. Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration. Authors: Ignasi Jorba, Milica Nikolic, Carlijn VC Bouten*

9. Mechanobiology of Exercise-Induced Cardiac Remodeling in Health and Disease. Authors: William K. Cornwell* III MD, MSCS; Peter Buttrick MD

10. Cardiac microvascular endothelial cells and pressure overload-induced cardiac fibrosis. Authors: Jaafar Al-Hasani and Markus Hecker*

11. Cellular and Subcellular Mechanisms of Ventricular Mechano-Arrhythmogenesis. Authors: Breanne A. Cameron Peter Kohl T Alexander Quinn*

12. Computational biomechanics of ventricular dyssynchrony and resynchronization therapy. Authors: Angela WC Lee Marina Strocchi Cristobal Rodero Caroline Mendonca Costa Steven A Niederer*

13. Therapeutic innovations for heart failure. Authors: Anca Remes*, Derk Frank, Oliver J. Muller