Main description:

Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure.

Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.

Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials.

Contents:

Contributor contact details
Woodhead Publishing Series in Biomaterials
Foreword
Introduction
Part I: Biomaterials for cardiac regeneration and repair

Chapter 1: Nanotechnology and nanomaterials for cardiac repair

Abstract:
1.1 Introduction
1.2 Electrospinning nanofibrous scaffolds
1.3 Conductive nanomaterial for myocardial infarction (MI)
1.4 Nanomedicine
1.5 Future trends


Chapter 2: Hydrogels for cardiac repair

Abstract:
2.1 Introduction
2.2 Hydrogels
2.3 Injectable hydrogels alone for cardiac repair
2.4 Hydrogels as a platform for co-delivery
2.5 Delivery strategies of hydrogels
2.6 Future trends
2.7 Sources of further information and advice


Chapter 3: Injectable biomaterials for cardiac regeneration and repair

Abstract:
3.1 Introduction
3.2 Design criteria for biomaterials in cardiac tissue engineering
3.3 Injectable biomaterials
3.4 Bioactive molecules used in cardiac tissue engineering
3.5 Hydrogels to promote endogenous cardiac regeneration and repair
3.6 Hydrogels for the delivery of cells for cardiac regeneration
3.7 Hydrogels for the artificial maintenance of ventricle geometry and repair
3.8 Future trends


Chapter 4: Biomaterials for enhancing endothelial progenitor cell (EPC) therapy for cardiac regeneration

Abstract:
4.1 Introduction
4.2 Endothelial progenitor cells (EPCs)
4.3 Enhancing EPC therapy
4.4 Future trends
4.5 Conclusion


Chapter 5: Endothelial progenitor cell (EPC)-seeded intravascular stents

Abstract:
5.1 Intravascular stents
5.2 Endothelial progenitor cells (EPCs)
5.3 EPC-seeded intravascular stents
5.4 Conclusion
5.5 Sources of further information and advice




Part II: Tissue engineering for cardiac regeneration and repair

Chapter 6: Biomaterials and cells for cardiac tissue engineering

Abstract:
6.1 Introduction
6.2 Cardiac structure
6.3 Cardiac remodeling in myocardial infarction (MI)
6.4 Cells for cardiac tissue engineering
6.5 Materials for cardiac tissue engineering
6.6 Creation of heart tissue using cell and biomaterials: an in vitro approach
6.7 Creation of heart tissue using cell and biomaterials: an in vivo approach of injectable matrices
6.8 Vascularization in myocardial tissue engineering
6.9 Ventricular aneurysm repair using cells and biomaterials
6.10 Clinical applications
6.11 Conclusion and future trends


Chapter 7: Decellularized biological scaffolds for cardiac repair and regeneration

Abstract:
7.1 Introduction
7.2 Methods of bioscaffold preparation
7.3 Cardiac repair with non-cardiac bioscaffolds
7.4 Tissue specificity of extracellular matrix bioscaffolds
7.5 Current methods for decellularizing cardiac tissue
7.6 Whole organ engineering


Chapter 8: Biomaterial scaffolds for cardiac regeneration and repair derived from native heart matrix

Abstract:
8.1 Heart failure and cardiac tissue engineering
8.2 Extracellular matrix (ECM) as a biomaterial
8.3 Cardiac ECM as a scaffold for cardiac tissue engineering
8.4 Hybrid scaffolds for cell delivery into the heart
8.5 Native heart ECM hydrogels for cardiac differentiation
8.6 Current limitations and future trends
8.7 Acknowledgments


Chapter 9: Cell sheet engineering for cardiac repair and regeneration

Abstract:
9.1 Introduction
9.2 Skeletal myoblasts
9.3 Cardiac progenitor cells and cardiac stem cell sheets
9.4 Other tissue stem/progenitor cells and cell sheets
9.5 Pulsatile cardiac cell sheet and transplantation into animal models
9.6 Cardiac differentiation from human embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs)
9.7 Engineered cardiac tissue using ESC/iPSC-derived cardiomyocytes
9.8 Future trends
9.9 Conclusion
9.10 Acknowledgements


Chapter 10: Maturation of functional cardiac tissue patches

Abstract:
10.1 Introduction
10.2 Native cardiac development
10.3 Engineering and functional maturation of biomimetic cardiac tissues
10.4 Promoting the maturation of cardiac tissue patches
10.5 MicroRNAs
10.6 Pluripotent stem cells and their associated molecular effectors
10.7 Mechanical forces and stiffness in cardiac tissue engineering
10.8 Conclusions and future trends
10.9 Acknowledgements


Chapter 11: Vascularizing engineered tissues for in vivo and in vitro applications

Abstract:
11.1 Introduction
11.2 Strategies to vascularize engineered tissues
11.3 In vitro applications
11.4 In vivo applications
11.5 Major barriers and future trends
11.6 Conclusion


Chapter 12: Clinical considerations for cardiac tissue engineering

Abstract:
12.1 Introduction
12.2 Heart muscle engineering concepts and applications
12.3 Cell types for clinical translation
12.4 Extracellular matrix from within or outside
12.5 In vivo studies in large animal models
12.6 Clinical translation
12.7 Future trends
12.8 Sources of further information and advice
12.9 Acknowledgements




Part III: Vascular remodelling for regeneration and repair

Chapter 13: Aortic extra cellular matrix (ECM) remodeling

Abstract:
13.1 Introduction
13.2 The aorta
13.3 Pathophysiological changes in thoracic aortic aneurysm (TAA) development
13.4 Extracellular matrix (ECM) remodeling
13.5 Protease activity
13.6 Regulation of protease activity
13.7 Challenges and pitfalls of clinical therapy
13.8 Conclusion


Chapter 14: Cell-biomaterial interactions for blood vessel formation

Abstract:
14.1 Introduction
14.2 Blood vessel architecture
14.3 Matrices to investigate vasculogenesis mechanisms
14.4 Matrices to direct in vitro prevascularization
14.5 Scaffolds to induce and study angiogenesis
14.6 Manipulating materials to guide vascular assembly and formation
14.7 Future trends
14.8 Conclusion


Chapter 15: Stem cells in tissue-engineered blood vessels for cardiac repair

Abstract:
15.1 Introduction
15.2 Development of biodegradable tissue-engineered vascular grafts (TEVGs)
15.3 Techniques for in vivo experiments and evaluation
15.4 Clinical application of TEVGs
15.5 Future trends
15.6 Sources of further information and advice


Chapter 16: Tissue-engineered cardiovascular grafts and novel applications of tissue engineering by self-assembly (TESA (TM))

Abstract:
16.1 Introduction
16.2 Clinical setting
16.3 Current options and the need for alternative conduits
16.4 Evolution of cardiovascular tissue engineering
16.5 Tissue engineering by self-assembly (TESA (TM)): a scaffold-free technology
16.6 Clinical results with TESA (TM) technology
16.7 Future trends




Index