Main description:

Bridging academic research and industrial applications, this is the first modern approach to relate fundamental research to the applied science of colloids. Edited by the 'l'eminence grise' on this topic and written by the top scientists in the field, this text examines the role of colloid and interface science in pharmacy, as well as pharmaceutical formulations and drug delivery. It then goes on to treat pharmaceutical suspensions and emulsions, including multiple emulsions, as well as liposomes and the role of nanotechnology in drug delivery. A final section is devoted to the hot topic of stem cell research. For surface and pharmaceutical chemists, physicochemists, chemical engineers and those working in the pharmaceutical industry.

Contents:

Preface. List of Contributors. 1 Iron Oxide Nanoparticle Dispersions (Ignac Capek). 1.1 Introduction. 1.2 Preparation of Iron and Iron Oxide Nanoparticles. 1.3 Metal-Iron Oxide Nanoparticles. 1.4 Iron-Metal Alloys. 1.5 Polymer-Iron Oxide Nanoparticles. 1.6 Oxidation of Iron Oxide Particles. 1.7 Applications. 1.8 Particle Size Estimations. 1.9 Conclusions. 2 Solubilization of a Poorly Soluble Aromatic Drug by Micellar Solutions of Amphiphilic Block Copoly(oxyalkylene)s (David Attwood and Colin Booth). 2.1 Introduction. 2.2 Copolymers. 2.3 Micellization and Micelle Properties. 2.4 Drug Solubilization. 2.5 Method 2. 2.6 Gelation. 2.7 Conclusion. 3 Controlling the Physical Stability of Liposomal Colloids (Ferenc Csempesz and Istvan Puskas). 3.1 Introduction. 3.2 Experimental. 3.3 Results. 3.4 Conclusions. 4 Mathematical Modeling of Coagulation and Flocculation of Colloidal Suspensions Incorporating the Influence of Surface Forces (Venkataramana Runkana and Ponisseril Somasundaran). 4.1 Introduction. 4.2 Mathematical Model. 4.3 Results and Discussion. 4.4 Conclusions. 5 Emulsion Stability and Interfacial Properties - Application to Complex Emulsions of Industrial Interest (Daniele Clausse, Delphine Daniel-David, Francois Gomez, Ljepsa Komunjer, Isabelle Pezron, Christine Dalmazzone, and Christine Noik). 5.1 Introduction. 5.2 Macroscopic Characterization of Complex Emulsions: Properties and Stability. 5.3 Methods Used to Characterize Interfacial Properties. 5.3.1 Experimental Methods. 5.4 Impact of Interfacial Phenomena on the Stability of Complex Emulsions. 5.5 Conclusions. 6 Wetting Film Dynamics and Stability (Boryan Radoev, Klaus Werner Stockelhuber, Roumen Tsekov, and Philippe Letocart). 6.1 Introduction. 6.2 Dynamics of Wetting Films. 6.3 Stability of Wetting Films. 7 Measuring Forces in the Colloidal Regime with the Atomic Force Microscope (J. Mieke Kleijn, Marcel Giesbers, and Martien A. Cohen Stuart). 7.1 Introduction. 7.2 Force Measurements Using the AFM. 7.3 Forces in the Colloidal Regime. 7.4 Conclusion and Outlook. 8 Ion Specificity in Colloidal Systems (Johannes Lyklema and Frans A.M. Leermakers). 8.1 Introduction. 8.2 Lyotropic or Hofmeister Serie. 8.3 Some Literature Examples. 8.4 Modeling Ion Specificity at the Electrified Solid/Liquid Interface. 8.5 Outlook. 9 Stabilization of Thin Films, Foams, Emulsions and Bifluid Gels with Surface-active Solid Particles (Krassimir P. Velikov and Orlin D. Velev). 9.1 Introduction. 9.2 Absorption Behavior of Particles at Interfaces. 9.3 Mechanism of Stabilization of Foams and Emulsions by Spherical Particles. 9.4 Stabilization by Non-spherical Particles. 9.5 Multiple Emulsions Stabilized with Particles. 9.6 Bifluid Particle-stabilized Gels. 9.7 Conclusions and Outlook. 10 Forces in Aqueous Nanofilms Containing Polyelectrolytes (Dan Qu, Katarzyna Hanni-Ciunel, Daniel Rapoport, and Regine v. Klitzing). 10.1 Introduction. 10.2 Forces in Films. 10.3 Methods for Force Measurements. 10.4 Effect of Confinement. 10.5 Effect of Different Parameters on Film Forces. 10.6 Effect of Film Interface Properties. 10.7 Summary and Conclusions. 11 Association Between Polyelectrolytes and Oppositely Charged Surfactants in Bulk and at Solid/Liquid Interfaces (Per M. Claesson, Andra Dedinaite, Robert Meszaros, and Imre Varga). 11.1 Introduction. 11.2 Bulk Association. 11.3 Interfacial Association. 11.4 Conclusions. 12 Non-ionic Micelle Films: Thinning and Stability (Alex D. Nikolov and Darsh T. Wasan). 12.1 Introduction. 12.2 Micellar Film Thinning Probed by Capillary Force Balance. 12.3 Results and Discussion. 12.4 Conclusions. 13 PEGylated Polymer-based Nanoparticles for Drug Delivery to the Brain (Hyun Ryoung Kim, Karine Andrieux, and Patrick Couvreur). 13.1 Introduction. 13.2 Biodegradable Polymer-based PEGylated Nanoparticles. 13.3 Nanogels. 13.4 Active Targeting of PEGylated Nanoparticles. 13.5 Conclusions. Subject Index.