Main description:

Corneal Cross-Linking, Second Edition represents an innovative approach to treating primary acquired and secondary induced ectatic disorders. In addition, corneal cross-linking (CXL) has promising applications as an alternative in the treatment of corneal infectious and non-infectious melting, as well as conditions such as Fuchs' endothelial dystrophy.

The new and expanded Second Edition of Corneal Cross-Linking by Drs. Farhad Hafezi and J. Bradley Randleman will provide a concise yet comprehensive summary of the CXL process, including the basic science foundations, treatment protocols and outcomes, recognition and management of potential complications, and modification of standard protocol for special circumstances.

Given all the changes in this rapidly progressing field, many brief topics from the first edition have now grown into full chapters or sections. These include expanded sections on alternative treatment protocols, corneal imaging and biomechanics, combing cross-linking with other refractive treatments, and a section devoted specifically to the most highly debated controversies in the field today.

With each chapter being fully updated plus including over twenty new chapters that covers the latest advances and future directions, Corneal Cross-Linking, Second Edition represents the cutting-edge of CXL research and clinical practice.

"Since the publication of the first edition of this book in 2013, our knowledge of corneal cross-linking has again significantly increased, both scientifically and clinically. Today, concise recommendations (guidelines for cross-linking) help the clinician to select the patients, make decisions, and provide optimal treatment"
-Eberhard Spoerl, PhD and Theo Seiler, MD, PhD

Contents:

Dedication

About the Editors

About the Associate Editor

Contributing Authors

Foreword by Eberhard Spoerl, PhD, and Theo Seiler, MD, PhD

Introduction

Section I Basic Principles of Corneal Biomechanics and Corneal Cross-Linking

Chapter 1 History of Corneal Cross-Linking

Eberhard Spoerl, PhD, and Frederik Raiskup, MD, PhD, FEBO

Chapter 2 Introduction to Corneal Biomechanics

William J. Dupps Jr, MD, PhD

Chapter 3 Fundamental Principles of Corneal Cross-Linking

Gregor Wollensak, MD

Chapter 4 Riboflavin, Ultraviolet Light, and the Photochemical Reaction

Arie L. Marcovich, MD, PhD, and Alexander Brandis, PhD

Chapter 5 The Role of Oxygen in Corneal Cross-Linking

Olivier Richoz, MD, PhD; Sabine Kling, PhD; and Farhad Hafezi, MD, PhD

Chapter 6 Cross-Linking Initiated by Other Chromophores and by Multiphoton Excitation

Irene Kochevar, PhD

Chapter 7 Corneal Cross-Linking Safety Considerations

Christina Giannikas Starcic, MD; Leejee H. Suh, MD; and Stephen L. Trokel, MD

Chapter 8 Molecular Aspects of Corneal Cross-Linking

Rohit Shetty, FRCS, PhD; Natasha Kishore Pahuja, DOMS; and Harsha Nagaraja, MS, FCE

Chapter 9 Evaluation and Diagnosis of Keratoconus and Pellucid Marginal Degeneration

Marcony R. Santhiago, MD, PhD; Yaron S. Rabinowitz, MD; and J. Bradley Randleman, MD

Chapter 10 Evaluation and Diagnosis of Postoperative Corneal Ectasia

J. Bradley Randleman, MD; Maria A. Woodward, MD, MS; and Marcony R. Santhiago, MD, PhD

Section II Corneal Cross-Linking for Corneal Ectasias

Chapter 11 Corneal Cross-Linking for Progressive Keratoconus

Tobias Koller, MD; Stefan Seiler, MD; and Theo Seiler, MD, PhD

Chapter 12 Corneal Cross-Linking for Postoperative Corneal Ectasia

David Tabibian, MD, and Farhad Hafezi, MD, PhD

Chapter 13 Corneal Cross-Linking for Pellucid Marginal Degeneration

Leopoldo Spadea, MD, and Roberto Secondi, MD

Section III Corneal Cross-Linking Protocols and Complication Management

Chapter 14 The Standard Protocol and Its Parameters

Maria A. Woodward, MD, MS; David L. DeMill, MD; Francis W. Price Jr, MD; and

Marianne O. Price, PhD, MBA

Chapter 15 Corneal Cross-Linking Using Accelerated Protocols

George D. Kymionis, MD, PhD; Konstantinos I. Tsoulnaras, MD; and
Chrysanthi Koutsandrea, MD, PhD

Chapter 16 Epithelium-On Protocols: Conceptual/Basic Science

Eberhard Spoerl, PhD, and Suphi Taneri, MD

Chapter 17 Transepithelial Corneal Cross-Linking in Progressive Keratoconus

Frederik Raiskup, MD, PhD, FEBO

Chapter 18 Corneal Cross-Linking With Iontophoresis

Paolo Vinciguerra, MD; Riccardo Vinciguerra, MD; Fabrizio Camesasca, MD; Vito Romano, MD;
and Pietro Rosetta, MD

Chapter 19 Cross-Linking Protocols in Thin Corneas

Soosan Jacob, MS, FRCS, DNB, and Amar Agarwal, MS, FRCS, FRCOphth

Chapter 20 Pediatric Corneal Cross-Linking

Joseph Frucht-Pery, MD, and Denise Wajnsztajn, MD

Chapter 21 Corneal Cross-Linking Complications and Management

Karolinne Maia Rocha, MD, PhD; Koray GUEmUEs, MD, FEBOphth; and J. Bradley Randleman, MD

Section IV Corneal Cross-Linking Imaging and Diagnostic Evaluations

Chapter 22 Measuring the Efficacy of Corneal Cross-Linking Using Advanced Corneal
Biomechanical Diagnostic Modalities

Renato AmbrOsio Jr, MD, PhD; Marcella Q. SalomAo, MD; and Cynthia Roberts, PhD

Chapter 23 Measuring the Efficacy of Cross-Linking: Clinical Metrics

J. Bradley Randleman, MD, and Praneetha Thulasi, MD

Chapter 24 Measuring Corneal Cross-Linking Efficacy: Biomechanical Measurement Approach

Giuliano Scarcelli; Seok Hyun Yun; and J. Bradley Randleman, MD

Chapter 25 Confocal Microscopy in Corneal Cross-Linking

Cosimo Mazzotta, MD, PhD, and Luigi Fontana, MD, PhD

Chapter 26 Optical Coherence Tomography Use in Corneal Cross-Linking

Sumitra S. Khandelwal, MD, and J. Bradley Randleman, MD

Chapter 27 Epithelial Remodeling After Corneal Cross-Linking

Karolinne Maia Rocha, MD, PhD, and Sudeep Dilip Sunthankar, MD

Section V Cross-Linking Plus: Combination Procedures

Chapter 28 Corneal Cross-Linking in Combination With Transepithelial Phototherapeutic Keratectomy:
Cretan Protocol

George D. Kymionis, MD, PhD; Michael A. Grentzelos, MD;
and Chrysanthi Koutsandrea, MD, PhD

Chapter 29 Corneal Cross-Linking in Combination With Surface Ablation: Athens Protocol

Anastasios John Kanellopoulos, MD, and George Asimellis, PhD

Chapter 30 Corneal Cross-Linking in Combination With Intracorneal Ring Segment

Aylin KiliC, MD, and David Touboul, MD

Chapter 31 Corneal Cross-Linking in Combination With Phakic Intraocular Lenses

Jose L. GUEell, MD, PhD; Merce Morral, MD, PhD; Emilio J. Segovia, MD; Oscar Gris, MD, PhD;
Daniel Elies, MD; and Felicidad Manero, MD

Chapter 32 Corneal Cross-Linking: Combined Treatment Options

Efekan Coskunseven, MD, and Onurcan Sahin, MSc

Chapter 33 Corneal Cross-Linking as a Primary Refractive Procedure

George D. Kymionis, MD, PhD; Dimitra M. Portaliou, MD, PhD, FEBO; Michael A. Grentzelos, MD;
and Chrysanthi Koutsandrea, MD, PhD

Section VI Cross-Linking for Infectious Keratitis: PACK-CXL

Chapter 34 PACK-CXL

Jes Mortensen, MD, and Karim Makdoumi, MD, PhD

Chapter 35 PACK-CXL for Viral Keratitis and Acanthamoeba Keratitis

Francis W. Price Jr, MD, and Marianne O. Price, PhD, MBA

Section VII Other Uses for Cross-Linking

Chapter 36 Corneal Cross-Linking for Corneal Stromal Edema

Niels Ehlers, MD, PhD, and Jesper Hjortdal, MD, PhD

Chapter 37 Sclera Cross-Linking

Brendan Geraghty, BEng(Hons), MSc, PhD, and Ahmed Elsheikh, BEng(Hon), MSc, PhD

Section VIII Current Controversies and Perspectives

Chapter 38 Epithelium-On Treatments

In Favor

Steven E. Wilson, MD, and Andre A.M. Torricelli, MD, PhD

Opposed

Aldo Caporossi, MD, PhD, FRCS; Antonio Villano, MD; Stefano Baiocchi, MD, PhD;
and Orsola Caporossi, MD, PhD

Chapter 39 Corneal Cross-Linking Can Impact Limbal Stem Cells

In Favor

Johnny E. Moore, FRCOphth, PhD; David Schiroli, PhD; and C.B. Tara Moore, PhD

Opposed

Farhad Hafezi, MD, PhD, and Sabine Kling, PhD

Chapter 40 Performing Corneal Cross-Linking After Definitive Signs of
Ectasia Progression Are Detected

Renato AmbrOsio Jr, MD, PhD; Rosane de Oliveira CorrEa, MD;
and Rozalia Litewski Beildeck, MD

Chapter 41 Prophylactic Cross-Linking Combined With LASIK

In Favor

Anastasios John Kanellopoulos, MD, and George Asimellis, PhD

Opposed

Theo Seiler, MD, PhD

Chapter 42 Summary of Commercially Available Corneal Cross-Linking Units

George O. Waring IV, MD, FACS; Susannah L. Brown, MD;
and Frederik Raiskup, MD, PhD, FEBO

Financial Disclosures

Index