Main description:

This book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a "wash-in effect" (an increased penetration of contaminant). Decontamination with other substances (e.g. RSDL) is explored, and factors that affect dermal penetration (e.g. anatomical variation) are summarized. All systematic reviews are comprehensive and up-to-date.
Dermal Absorption and Decontamination will be useful for many fields and disciplines. Firstly, information on dermal decontamination may be used by governments for military and national defense purposes in the event of chemical warfare. Additionally, this information would be of use to many production companies, whose employees are at risk of an accident with toxic industrial chemicals. Topics covered in the book will also be of use to pharmaceutical companies, especially those exploring transdermal delivery of drugs and is of great relevance to those in the medical field, particularly dermatologists.

Contents:

Written:
1. Efficacy of Water Based Skin Decontamination Using In Vivo Animal Models: A Systematic Review (Anuk Burli, Nadia Kashetsky, Aileen Feschuk, Rebecca. Law, Howard Maibach)2. Efficacy of Water-Only or Soap and Water Skin Decontamination of Chemical Warfare Agents or Simulants Using In Vitro Human Models: A Systematic Review. (Chavy Chiang, Nadia Kashetsky, Aileen Feschuk, Anuk Burli, Rebecca Law, Howard Maibach) 3. Efficacy of Water Based Skin Decontamination of Occupational Chemicals Using In Vitro Human Skin Models: A Systematic Review. (Chavy Chiang, Nadia Kashetsky, Aileen Feschuk, Anuk Burli, Rebecca Law, Howard Maibach) 4. Efficacy of Water Based Skin Decontamination in In Vitro Animal Models (Maxwell Green, Nadia Kashetsky, Aileen Feschuk, Howard Maibach) 5. Comparative Efficacy of RSDL: A Systematic Review (Aileen Feschuk, Rebecca Law, Howard Maibach)6. Regional Variation in Percutaneous Absorption Using In Vitro Human Models: A Systematic Review. (Aileen Feschuk, Nadia Kashetsky, Chavy Chiang, Anuk Burli, Halie Burdick, Rebecca Law, Howard Maibach) 7. Regional Variation in Cutaneous Blood Flow in Healthy Patients: A Systematic Review (Halie Burdick, Rebecca Law, Howard Maibach (Aileen Feschuk, Nadia Kashetsky, Anuk Burli, Chavy Chiang (order undetermined))
To be written:
1) Regional variation in trans-epidermal water loss2) Regional variation in eccrine sweat3) Regional variation in apocrine sweat4) Regional variation in "other" physical properties5) Regional variation in irritation syndrome (irritant dermatitis)6) Regional Variation in allergic contact dermatitis 7) Regional variation in dermal cytokines and chemokines 8) Regional variation in dermal biochemistry 9) Regional variation in dermal electrolytes 10) Regional variation in hair follicles 11) Regional variation in aberrant apocrine glands 12) Regional variation in dermal glucose levels