Main description:

This volume provides a variety of technical approaches to study dopamine system function and dysfunction. Chapters guide readers through dopamine release in ex vivo and freely moving animals, multi-recording devices for in vivo simultaneous single cell and population activity, in silico modeling of dopamine neurons activity, neuroanatomical approaches, unbiased stereology, ultrastructural analyses of dopaminergic neurons, and axonal innervation. Additionally, chapters also incorporate pharmacological tools to model neuropsychiatric diseases, novel behavioral paradigms to dissect dopamine's role in behavior, and functional imaging to follow human dopamine system development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Comprehensive and cutting-edge, Dopamine Neurotransmission aims to be a valuable resource for researchers in various disciplines.

Contents:

Part I : Neuroanatomy

1 Ultrastructural Study of Dopaminergic Axon Terminals

Natalie Doig and Max Larsson

2 Quantifying Dopaminergic Innervation in Rodents Using Unbiased Stereology

Lauren M. Reynolds, Andrea Haree Pantoja-Urban, Del MacGowan, Colleen Manitt. Dominique Nouel and Cecilia Flores

3 Dendrites Crossing Borders: Quantifying The Distribution of Individual Dopaminergic Neurons' Dendritic Tree in Pars Compacta and Pars Reticulata

Rafael Ignacio Gatica, Guillermo Lazcano, and Pablo Henny

Part II: Cell physiology

4 Characterizing Dopamine Transporter Mediated Uptake and Efflux in Brain Slices: A New Approach

Nora Awadallah, Jose A. Pino, Dimitri N. Koutzoumis, and Gonzalo E. Torres

5 Modeling Pacemaking, Bursting and Depolarization Block in Midbrain Dopamine Neurons

Christopher Knowlton and Carmen C. Canavier

6 Electrophysiological Characterization of Dopaminergic Neurons of the Rat Substantia Nigra Compacta

Marcelo Aguilar-Rivera, Rafael Gatica, Victor Azocar, Darinka Buc, and Jose Antonio Fuentealba

Part III: Models for addiction and neuropsychiatric diseases

7 Pulmonary Inhalation to Assess Effects of Coca-Paste On Behavior and Dopamine Neurotransmission

Cecilia Scorza, Jose Pedro Prieto, Sara Fabius, and Martin Galvalisi

8 Ethanol Intake On Preclinical Models: Methods of Assessment and Effects On Dopamine Signaling

Ricardo M Pautassi, Aranza Wille-Bille, Macarena S Fernandez, and Maria Carolina Fabio

9 Preclinical models of THC and Nicotine Exposure During Adolescent Brain Development: Modelling Neuropsychiatric Phenotypes Related to Dopaminergic Transmission

Enzo Perez-Valenzuela and Steven R. Laviolette

10 The MAM Model to Study the Role of Dopamine in Schizophrenia

Xihu Zhu, Daniela L. Uliana, and Anthony A. Grace

Part IV: Circuit level and behavior

11 Fast Scan Cyclic Voltammetry to Assess Dopamine Function: From Circuits to Behavior

Philip J. Clark and Rodrigo A. Espana

12 Multi-circuit Recording in Animal Models of Parkinson

Ximena Paz Garcia-Nunez, Carolina Astudillo-Valenzuela, and Romulo Fuentes-Flores

13 Neuroimaging Human Dopamine-Related Neurophysiology across Development

Ashley Parr, Bart Larsen, Finn Calabro, Brenden Tervo-Clemmens, and Beatriz Luna

14 Dopaminergic Control of Actions and Habits

Fabien Naneix and Etienne Coutureau