Main description:

This third edition volume expands on the previous editions with a discussion of new and updated methods used to study drug delivery. Chapters cover topics such as drug delivery in cancer and intrathecal delivery of analgesics in humans. The increasing role of nanobiotechnology is reflected in eight of the sixteen chapters that include synthesis of gold nanoparticles; targeted siRNA delivery; and lipid nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and thorough, Drug Delivery Systems: Methods and Protocols, Third Edition is a valuable resource for scientists working in industry or academia, and physicians involved in research and clinical care of patients.

Contents:

Preface...
Table of Contents...
Contributing Authors...

1. An Overview of Drug Delivery Systems
Kewal K. Jain

2. Role of Nanobiotechnology in Drug Delivery
Kewal K. Jain

3. Intrathecal Drug Delivery
Jose De Andres, Ruben Rubio-Haro, Carmen De Andres-Serrano, Marcos Juan Asensio-Samper, and Gustavo Fabregat-Cid

4. Microanatomy Relevant to Intrathecal Drug Delivery
Miguel A. Reina, Andre Boezaart, Carmen De Andres-Serrano, Ruben Rubio-Haro, and Jose De Andres

5. Drug Delivery Applications of Nanoparticles in the Spine
Indu Venugopal, Ankit I. Mehta, and Andreas A. Linninger

6. Synthesis of Gold Nanoparticle: Peptide Drug Conjugates for Targeted Drug Delivery
K. Kalishwaralal, G. Luboshits, and M.A. Firer

7. A Method for Targeted Non-Viral siRNA Delivery in Cancer and Inflammatory Diseases
Rima Kandila, Yuran Xie, Aditi Mehta, and Olivia M. Merkel

8. Tumor-Targeted Dendrimer Nanoparticles for Combinatorial Delivery of siRNA and Chemotherapy for Cancer Treatment
Narsireddy Amreddy, Rebaz A. Ahmed, Anupama Munshi, and Rajagopal Ramesh

9. Sonoporation for augmenting Chemotherapy of Pancreatic Ductal Adenocarcinoma
Jason Castle, Spiros Kotopoulis, and Flemming Forsberg

10. Preparation of Cholera Toxin Subunit B Functionalized Nanoparticles for Targeted Therapy of Glioblastoma
Juan Guan, Jun Qian, and Changyou Zhan

11. Microfluidic-Manufacturing of Multi-Targeted PLGA/PEG Nanoparticles for Delivery of Taxane Chemotherapeutics
Claudia Martinsa and Bruno Sarmento

12. Computer-Aided Design of Nanoparticles for Transdermal Drug Delivery
Rakesh Gupta and Beena Rai

13. Microneedle Mediated Transdermal Delivery of Tizanidine Hydrochloride
Hetal Thakkar, Kartik Pandya, and Brijesh Patel

14. Targeted siRNA Delivery using Lipid Nanoparticles
Andreia Jorge, Alberto Pais, and Carla Vitorino

15. Lipid Nanocarriers for Enhanced Delivery of Temosolomide to the Brain
Archana Khosa, Kowthavarapu V. Krishna, Sunil Kumar Dubey, and Ranendra Narayan Saha

16. Construction of a Macrophage-Targeting Bio-Nanocapsule-Based Nanocarrier
Hao Li, Masaharu Somiya, Kenji Tatematsu, and Shun'ichi Kuroda