Main description:

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more.

Contents:

1. Primary hepatocytes and their cultures for the testing of drug-induced liver injury Vania Vilas-Boas, Axelle Cooreman, Eva Gijbels, Raf Van Campenhout, Emma Gustafson, Steven Ballet, Pieter Annaert, Bruno Cogliati and Mathieu Vinken 2. Cell death in drug-induced liver injury Andrea Iorga and Lily Dara 3. Drug-induced liver injury in obesity and nonalcoholic fatty liver disease Julien Allard, Dounia Le Guillou, Karima Begriche and Bernard Fromenty 4. Role and mechanisms of autophagy in alcohol-induced liver injury Xiaojuan Chao and Wen-Xing Ding 5. Mechanisms of idiosyncratic drug-induced liver injury Jack Uetrecht 6. Idiosyncratic drug-induced liver injury in patients: detection, severity assessment, and regulatory implications Paul B. Watkins 7. Acetaminophen hepatotoxicity: A mitochondrial perspective Anup Ramachandran and Hartmut Jaeschke 8. Biomarkers of drug-induced liver injury Mitchell R. McGill and Hartmut Jaeschke 9. Mechanisms and biomarkers of liver regeneration after drug-induced liver injury Melissa M. Clemens, Mitchell R. McGill and Udayan Apte 10. Evaluation and treatment of acetaminophen toxicity Erik S. Fisher and Steven C. Curry