Main description:

This comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice.

Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers.

Contents:

The History of Blood Transfusions

Modern Blood Banking

Component Therapy and Whole Blood: Packed Red Blood Cells, Fresh Frozen Plasma, Cryoprecipitate, washed and or radiated red cells

The Coagulation System and Clot Stability

Fibrinolysis- Tranexamic Acid and Aminocaproic Acid.

Hypercoagulation and Thrombotic Disorders: TTP, Factor 5 Leiden, Phospholipid Syndrome, Anti-thrombin 3, hypereosinophils, oxidative stress, cancer.

Diseases or Conditions of Platelet Dysfunction

The Massive Transfusion Protocol

New Biologicals to Assist Clotting- Riastap, Prothrombin Concentrates. Antithrombin3, Fibrogammin and factor13, Fibrosupernatant, Fibrinogen Concentrates, Recombinant Factor 7, DDAVP, Octaplast G., Factor 10A, KCentra

Biologicals that Inhibit Clot generation -The Heparins, Factor 10A inhibitors, rivaroxaban, apixaban, dabigatran,

Point of Care Testing and Goal Directed Therapy- Thromboelastography, ROTEM, Platelet function analyzer, stat-PT, thrombin generation assays, multi-electro-aggregometry, OHP (Overall hemostatic potential assay), ACT.

Complications of Blood Transfusions: TRALI, TACO, Blood type mismatch, infection

Diseases of the Coagulation System- Hemophilia, VonWillebrand Disease, Cryoglobulinemia, Inborn Errors of Factor Synthesis

Blood Conservation Strategies and Bloodless Surgery- normovolemic hemodilution, cell saver,

Bridges to Transfusion when blood is not immediately available.

Artificial Blood

Preoperative correction of anemia

Blood Deployment in Natural Disasters and the Military in Combat

Commonly prescribed medications that affect clotting-anti-depressants, NSAIDS, ASA

Anesthesia for the severe trauma patient- new evidence from new trials

Old blood vs. new blood- Is storage injury a concern?

Vascular Endothelial dysfunction and inflammatory states

Liberal or restrictive blood transfusions