Main description:

This book provides a concise yet comprehensive overview of frailty and sarcopenia in the cirrhotic patient. The text presents a personalized approach to identifying cirrhotic patients at risk of higher morbidity and mortality due to frailty and sarcopenia. It reviews current and novel diagnostic methods, while spotlighting treatment and management strategies for frailty and sarcopenia. The book also focuses on special issues associated with these syndromes, such as the effect of gender, age, and ethnicity on frailty and sarcopenia, sarcopenic obesity, and frailty and sarcopenia after liver transplantation. Future considerations are outlined in the closing chapters, including emerging pharmacological and interventional therapies for these syndromes.

Written by experts in the field, Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future is a valuable resource for clinicians and practitioners who treat patients with cirrhosis.

Contents:

I The Basics
1 Definition & Diagnosis of Sarcopenia in the Research and Clinical SettingsAldo J. Montano-Loza, Maryam Ebadi 2 The Definition and Diagnosis of Frailty in the Research and Clinical SettingsHui-Wei Chen, Andres Duarte-Rojo
3 Deciphering the Cirrhotic Patient's Present Status: The Overlap between Physical Frailty, Disability and SarcopeniaElliot B. Tapper
4 The Pathogenesis of Physical Frailty and SarcopeniaSrinivasan Dasarathy
5 Prognostic Implications of Physical Frailty and Sarcopenia Pre and Post TransplantationStefan Buettner, Jan N.M. IJzermans, Jeroen L.A. van Vugt
6 Nutritional Therapy in the Management of Physical Frailty and SarcopeniaManuela Merli, Barbara Lattanzi, Daria D'Ambrosio, Nicoletta Fabrini, Alice Liguori
7 Exercise Training in Patients with CirrhosisGraeme M. Purdy, Kenneth J. Riess, Kathleen P. Ismond, Puneeta Tandon
II The Challenges
8 Sex, Age and Ethnicity Dependent Variation in Body Composition: Can There Be a Single Cut-off?Maria Cristina Gonzalez, Jingjie Xiao, Ilana Roitman Disi
9 Muscle Mass versus Muscle Strength and Performance: Is Muscle Mass Measurement Alone Enough?Matthew Kappus, Pranab Barman
10 The Role of Changes in Subcutaneous and Visceral Adiposity, Sarcopenic Obesity and Myosteatosis/Muscle Quality in Cirrhosis: How to Diagnose It and Its Contribution to PrognosisMaryam Ebadi, Aldo J. Montano-Loza
11 Evidence for the Assessment of Physical Frailty and Sarcopenia in Hospitalized Patients and the Role of Assessing Changes Over TimeGuido Stirnimann
12 Frailty and Sarcopenia in the Selection of Candidates for Liver TransplantationChristopher J. Sonnenday
13 Physical Frailty and Sarcopenia in End Stage Liver Disease: Do They Improve after Liver Transplantation?Rahima A. Bhanji, Elizabeth J. Carey
14 Measures of Sarcopenia: The Utility of Ultrasound, Bioelectrical Impedance Analysis, and Single-Slice Cross-Sectional Imaging Marina Mourtzakis, Kirsten Elizabeth Bell
III The Future
15 Upcoming Pharmacological and Interventional Therapies for the Treatment of Physical Frailty and SarcopeniaPenelope Hey, Marie Sinclair
16 Should Frailty Include Multidimensional and Dynamic Factors?Darryl B. Rolfson
17 Hepatic Encephalopathy, Sarcopenia and FrailtyChantal Bemeur, Christopher F. Rose
18 A Research Wish List to Understand, Diagnose and Manage Frailty and SarcopeniaMichael A. Dunn