Main description:

This book explores several aspects of the research in the field of general anesthesia, including mechanisms of action of inhaled and intravenous hypnotic agents; the anesthetics-induced neurotoxicity in children and elderly; features and physiopathology of postoperative cognitive side effects; and findings from preclinical research focused on the recognition of potential links between anesthetics and cancer cell biology. Furthermore, chapters in this book cover technical topics such as preoperative monitoring of autonomic nervous activity; EEG based monitoring of general anesthesia; monitoring cerebral oximetry by near infrared spectroscopy; pharmacological issues of anesthesia interest; and optimization of perioperative course through the latest techniques such as the opioid-free anesthesia. Finally, this book offers a comprehensive and up-to-date discussion on the phenomenon of general anesthesia awareness and its potential psychological sequelae. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and comprehensive, General Anesthesia Research is a valuable resource for novice and expert anesthesiologists who want to learn more about the important advances made in this developing field.

Contents:

Series Preface...
About the Editor...
Preface...
Table of Contents...
Contributing Authors...

1. The Challenge of Accidental Awareness during General Anesthesia
Marco Cascella

2. Impact of Anesthetics on Brain Electrical Activity and Principles of pEEG-Based Monitoring during General Anesthesia
Marco Cascella

3. Perioperative Monitoring of Autonomic Nervous Activity
Theodoros Aslanidis

4. Monitoring Cerebral Oximetry by Near Infrared Spectroscopy (NIRS) in Anaesthesia and Critical Care: Progress and Perspectives
Antonio Pisano, Diana Di Fraja, and Concetta Palmieri

5. Post-Traumatic Stress Disorder following Intraoperative Awareness
Helene Vulser and Gaele Lebeau

6. Mechanisms of Action of Inhaled Volatile General Anesthetics: Unconsciousness at the Molecular Level
Daniela Baldassarre, Giuliana Scarpati and Ornella Piazza

7. Intravenous Hypnotic Agents: From Binding Sites to Loss of Consciousness
Daniela Baldassarre, Filomena Oliva, and Ornella Piazza

8. Pharmacological Considerations for the Use of General Anesthetics in the Elderly
Francesca Guida, Enza Palazzo, Serena Boccella, Livio Luongo, Giulio Scala, Francesca Gargano, Gorizio Pieretti, Ida Marabese, Mariantonietta Scafuro, Vito de Novellis, and Sabatino Maione

9. Propofol Effects in Breast Cancer Cell Progression: Evidences from In Vitro Studies
Sabrina Bimonte, Marco Cascella, Aldo Giudice, Francesca Bifulco, Stefan Wirz, and Arturo Cuomo

10. Postoperative Cognitive Function following General Anesthesia in Children
Maiko Satamoto

11. The Challenge of Opioid-Free Anesthesia
Maher Khalife, Graziela Biter, Marco Cascella, and Raffaela Di Napoli

12. New Insights into the Pharmacology of Dexmedetomidine and Open Issues for Neurosurgical Procedures
Mariantonietta Scafuro, Francesca Gargano, and Marco Fiore

13. Transgenic Mouse Models, General Anesthetics and Alzheimer Disease: Findings from Preclinical Studies
Sabrina Bimonte, Antonio Barbieri, Nagoth Joseph Amruthraj, Marco Cascella, Arturo Cuomo, and Claudio Arra

14. The Biochemical Basis of Delirium
Matthew Umholtz and Nader D. Nader

15. Postoperative Delirium and Postoperative Cognitive Dysfunction
Matthew Umholtz and Nader D. Nader