Main description:

This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.

Contents:

Section I. Overview1. An overview of genome editing in cardiovascular and metabolic diseases

Section II. Bioinformatics

2. Bioinformatics research methodology of genome editing in cardiovascular and metabolic diseases

3. Online databases of genome editing in cardiovascular and metabolic diseases

4. Application of systems biology for genome editing involved in regulating of cardiovascular and metabolic diseases

5. Bioinformatics for reducing off-targets in cardiovascular and metabolic diseases

Section III. Genome editing in cardiovascular disease

6. Genome editing and cardiac regeneration

7. Genome editing and myocardial development

8. Genome editing and heart failure

9. Genome editing and pathological cardiac hypertrophy

10. Genome editing and cardiac remodeling

11. Genome editing and diabetic cardiomyopathy

12. Genome editing and cardiac arrhythmias

13. Genome editing and atrial fibrillation

14. Genome editing and muscle atrophy

Section IV. Genome editing in metabolic diseases

15. Genome editing and obesity

16. Genome editing and fatty liver

17. Genome editing and diabetes

18. Genome editing and gout

19. Genome editing and protein energy malnutrition

Section V. Therapeutic implications

20. Genome therapy and cardiovascular diseases

21. Therapeutics in metabolic diseases

22. Gene editing and human iPSCs in cardiovascular and editing diseases

Section VI. Future Prospects

23. Prospective advances in genome editing investigation