Main description:

Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles and applications - as well as the advantages and disadvantages - of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and faculties of science at colleges and universities. This volume in the Pocket Guides to Biomedical Sciences series will help demystify these technologies. The book fills the gap between established conventional methods and the novel and exciting newly introduced tools of genome editing and gene drives. It will help young scientists understand the emerging genome-editing tools and gene drives, thereby promoting related research and adoption.

Key Features

Extensively reviews the current genome-editing tools and gene drives

Clarifies the targeting mechanisms and specificity of genome-editing tools

Details many different types of natural and synthetic gene drives

Highlights concerns with gene drives and genome-editing tools

Related Titles

Brown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4)

Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6)

Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4)

Contents:

Chapter 01 Genome editing

Chapter 02 Zinc Finger Nucleases

Chapter 03 Talens

Chapter 04 megaTALs/ meganucleases

Chapter 05 CRISPR

Chapter 06 Comparison of ZFNs, TALENs, CRISPR, and megaTALs

Chapter 07 Gene Drives

Chapter 08 Supernumerary B chromosomes

Chapter 09 Suppression drive

Chapter 10 Maternal Effect Dominant Embryonic Arrest (Medea) system

Chapter 11 Heritable microorganisms: Wolbachia

Chapter 12 CRISPR gene drives

Chapter 13 The Killer-Rescue system