Main description:

The Genomic and Molecular Cardiovascular Medicine largely focuses on pertinent genomic and molecular aspects of cardiovascular medicine relevant to all levels of clinical practice, from primary care to preventive healthcare. The book also focuses on practice applications of translational genomic and molecular developments and advances that impact on cardiovascular system structure and function. Each chapter is evidence-based and comprehensive, with in-depth, cutting-edge knowledge relevant to the practice of clinical cardiology and cardiovascular surgery. The book aims to fill a major gap of knowledge resource focused on genomic and molecular aspects of contemporary cardiovascular medicine and surgery practice.

In view of scientific and technical complexities of the field, the book is written by a team of globally acknowledged experts in respective clinical, investigative, therapeutic and preventive aspects. The current practices within cardiovascular medicine and surgery offer excellent opportunity for genomic and molecular applications to achieve the high order effectiveness with maximum efficiency.

Contents:

1. Introduction to genomic and molecular biology
2. Methods in genomic and molecular medicine
3. Structure and function of the cardiovascular system
4. Molecular embryology of the cardiovascular system
5. Molecular mechanisms of cardiac electrical generation, conduction and regulation
6. Ion channel genomics and proteomics
7. Molecular structure and function of the myocardium
8. Molecular correlations of the myocardium with skeletal and smooth muscles
9. Genetic and molecular basis of metabolic and nutritional cardiovascular regulation
10. Genetic and molecular pathophysiology of heart failure
11. Molecular aspects of arterial, venous and lymphatic circulation
12. Molecular mechanisms and pathophysiology of pulmonary arterial and venous hypertension
13. Molecular perspectives of the cardiovascular inflammation
14. Molecular mechanisms of cardiovascular system response to hyperlipidemia and hyperglycemia
15. Molecular pathology of coronary (ischemic) artery disease (CAD)
16. Molecular basis of the adverse drug and toxin response of the cardiovascular system
17. Precision and personalise cardiovascular medicine including Molecular cardiovascular therapeutics
18. Novel cellular and molecular cardiovascular therapeutics
19. Genomic and Molecular basis of cardiovascular phenotype ontology
20. Preventive and public health applications of the genomic and molecular cardiovascular medicine (including social, ethical and legal aspects)
21. Glossary- selection and explanation of pertinent terms & phrases