Main description:

Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS -as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane.

They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity.

Contents:

1. Introduction
2. Glycosphingolipid Structure and Metabolism
3. Glycosphingolipid Distribution in the Central Nervous System
4. Functions of Glycosphingolipids in the Central Nervous System
5. Functional Mechanisms of Glycosphingolipids
6. Glycosphingolipids and Central Nervous System-Related Diseases
7. Synthetic Glycosphingolipid Probes and Their Biological Applications
8. Concluding Remarks