Main description:

The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90.

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Contents:

SECTION I: ONCOGENIC ASPECTS OF HSP90

Chapter 1. Regulatory Roles Of HSP90-rich Extracellular Vesicles

Takanori Eguchi, Kisho Ono, Kazumi Kawata, Kuniaki Okamoto and Stuart K Calderwood

Department of Dental Pharmacology and Advanced Research Center for Oral and Craniofacial Sciences

Dentistry and Pharmaceutical Sciences

Okayama University

Okayama, Japan

Chapter 2. HSP90-Based Heterocomplex As Essential Regulator For Cancer Disease

Mario D. Galigniana

Instituto de Biologia y Medicina Experimental (IBYME)-CONICET & Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales

Universidad de Buenos Aires

Buenos Aires, Argentina

Chapter 3. Therapeutic Potential Of Heat Shock Protein 90 Inhibitors In Colorectal Cancer Reyhaneh Moradi-Marjaneh, Seyed Mahdi Hassanian, Gordon A. Ferns, Amir Avan and Majid Khazaei Metabolic Syndrome Research Center and Cancer Research Center and Department of Modern Sciences and Technologies, Faculty of Medicine

And

Department of Physiology

Faculty of Medicine

Mashhad University of Medical Sciences

Mashhad, Iran

Chapter 4. Hsp90 In The Migration Of Primordial Germ Cells: A Model To Study Long-Distance Cell Migration And Perhaps Cancer?

Marie Lejong, Nathalie Vanmuylder and Stephane Louryan

Laboratory of Anatomy

Biomechanics and Organogenesis, Faculty of Medicine

Universite Libre de Bruxelles

Chapter 5. Role Of Heat Shock Protein 90 In Mammary Tumorigenesis

B.V. Sunil Kumar, Priya K. Gopal and Ramneek Verma

Department of Microbial and Environmental Biotechnology

School of Animal Biotechnology

Guru Angad Dev Veterinary and Animal Sciences University

Ludhiana, India

Chapter 6. Role Of HSP90 Inhibitors In The Treatment Of Cancer

Geraldine O'Sullivan Coyne, Cecilia Monge and Alice P. Chen

Division of Cancer Treatment and Diagnosis and Center for Cancer Research

National Cancer Institute

National Institutes of Health

Bethesda, USA

Chapter 7. p53-HSP90 Axis In Human Cancer

Amr Ghaleb and Natalia Marchenko

Department of Pathology

Stony Brook University

Stony Brook, USA

Chapter 8. HSP90 And Its Inhibitors For Cancer Therapy: Use Of Nano-delivery System To Improve Its Clinical Application

Prathap Somu and Subhankar Paul

Department of Biotechnology & Medical Engineering National Institute of Technology

Rourkela, India

Chapter 9. Hsp90 Is A Pivotal Player In Retinal Disease And Cancer

Asmaa Aboelnour, Ahmed E. Noreldin and Islam M. Saadeldin

Department of Animal Production

College of Food and Agricultural Science

King Saud University

Riyadh, Saudi Arabia

And

Department of Physiology, Faculty of Veterinary Medicine

Zagazig University

Zagazig, Egypt

Chapter 10. Targeting Hsp-90 Related Disease Entities For Therapeutic Development

Timothy Westlake, Mithcell Sun, Brandon C. Rosenblum, Zhengping Zhuang and Jared S. Rosenblum

Neuro-Oncology Branch, National Cancer Institute

National Institutes of Health

Bethesda, USA

Chapter 11. HSP90: A Key Player In Metal-Induced Carcinogenesis?

Abreu Pl, Ferreira LMR, Cunha-Oliveira T, Alpoim MC and Urbano AM

Department of Life Sciences and Molecular Physical Chemistry Research Unit

University of Coimbra

Coimbra, Portugal

Section II: Biomolecular Aspects of HSP90

Chapter 12. Hsp90 And Its Role In Heme-Maturation Of Client Proteins: Implications For Human Diseases

Arnab Ghosh and Dennis J. Stuehr

Department of Inflammation and Immunity

Lerner Research Institute

The Cleveland Clinic

Cleveland, USA

Chapter 13. Moonlighting Functions Of Heat Shock Protein 90

Chang Chen and Constance Jeffery

Department of Bioengineering

University of Illinois at Chicago

Chicago, USA

Chapter 14. Hsp90 As A Member Of Dicarboxylate Clamp TPR Protein Interaction Network: Implication In Human Diseases And Prospect As A Drug Target

Rajnish Kumar, Bengt Winblad and Pavel F. Pavlov

Memory Clinic

Theme Aging, Karolinska University Hospital

Huddinge, Sweden

Chapter 15. 'Complex World' Of Hsp90 Co-chaperone R2TP

Chrisostomos Prodromou

University of Sussex

Genome Damage and Stability Centre

Science Park Road, Brighton

Falmer, UK

Chapter 16. Functions Of SGT1, A Co-chaperone

Yohei Niikura and Katsumi Kitagawa

Greehey Children's Cancer Research Institute

Department of Molecular Medicine

UT Health San Antonio

San Antonio, USA

Chapter 17. Sti1/Hop Plays A Pivotal Role In Hsp90 Regulation Beyond Bridging Hsp70

Michael Reidy

Laboratory of Biochemistry and Genetics

National Institute of Diabetes and Digestive and Kidney Diseases

National Institutes of Health

Bethesda, USA

Section III: HSP90 in Natural Products Development

Chapter 18. Hsp90: A Target for Susceptibilities And Substitutions In Biotechnological And Medicinal Application

Athanasia Warnecke, Andreas Kirschning, Daniel Landsberg and Carsten Zeilinger

Leibniz University Hannover

Institute of Biophysic and Center of Biomolecular Drug Research Center (BMWZ)

Hannover, Germany

Chapter 19. Screening Technique For Heat Shock Protein 90 Inhibitors From Natural Products

Yue Hu, Xiao J. Zhang, Xiao T. Yang, Ying Y. Tang, Lin Y. Hu and Dong Zhu

School of Pharmacy, Nanjing University of Chinese Medicine and Jiangsu Key Laboratory for Functional Substance of Chinese Medicine and State Key Laboratory Cultivation Base for TCM Quality and Efficacy

Nanjing University of Chinese Medicine

Nanjing, China

Chapter 20. Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family

Bin Peng, Ying Wang, Yu-Ting Song, Xue Zhang, Fan-Fan Cao, Li-Min Xu, Mei Jiang, Xiao-Ling Bo, Georges Uzan and Deng-Hai Zhang

Sino-French Cooperative Lab

Shanghai Gongli Hospital

The Second Military Medical University

Shanghai, China

Section IV: Clinical Aspects of HSP90

Chapter 21. Hsp90 Chaperone In Disease

Luca Ferrari and Stefan G. D. Rudiger

Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research and Science for Life, Utrecht University

Utrecht, The Netherlands

Chapter 22. Theranostic Implications Of Heat Shock Proteins In Idiopathic Pulmonary Fibrosis

Ganapasam Sudhandiran, Divya Thomas, Vadivel Dineshbabu and Soumya Krishnan

Cell Biology Laboratory

Department of Biochemistry

University of Madras

Chennai, India

Chapter 23. Heat Shock Protein 90 And Reproduction In Female Animals: Ovary, Oocyte And Early Embryo

Yu-Wei Yang, Lu Chen and Cai-Xia Yang

College of Animal Science and Technology

Northeast Agricultural University

Harbin, China

Chapter 24. Heat Shock Protein 90 In Severe Trauma

Yan Zhao and Yuan-Guo Zhou

Molecular Biology Center

The State Key Laboratory of Trauma, Burn and Combined Injury

Research Institute of Surgery and Daping Hospital

Third Military Medical University

Chongqing, China

Chapter 25. HSP90 - Is There An Unknown Role In Pain Neurobiology

Joao Ferreira and Fani L. Moreira Neto

Instituto de Investigacao e Inovacao em Saude and IBMC - Instituto de Biologia Molecular e Celular

Universidade do Porto, Alameda Prof Hernani Monteiro

Porto, Portugal

Chapter 26. Heat Shock Protein 90 In Kidney Stone Disease

Visith Thongboonkerd

Medical Proteomics Unit, Faculty of Medicine Siriraj Hospital

Mahidol University

Bangkok, Thailand

Chapter 27. HSP90 et al. - Chaperome And Proteostasis Deregulation In Human Disease

Cindy Voisine and Marc Brehme

Department of Biology

Northeastern Illinois University

Chicago, USA