Main description:

This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.

Contents:

Chapter 1_Overview of homocysteine. -Chapter 2_Homocysteine and Folic acid metabolism. -Chapter 3_ Hyper-homocysteinemia and nutrition. -Chapter 4_ Metabolic disorders and Homocysteine. -Chapter 5_Bone Health and homocysteine. -Chapter 6_Biofortification, homocysteine and nutrition. -Chapter 7_ Homocysteinemia and autoimmune diseases. -Chapter 8_Homocysteine metabolism pathway genes in risk of type-2 diabetes mellitus. -Chapter 9_Role of homocysteine metabolism in cardiovascular diseases (CVD). -Chapter 10_ Homocysteine and thyroidism. -Chapter 11_Homocysteine metabolism and cancer. -Chapter 12_Stem cell and Homocysteine metabolism in treatment and management of diseases. -Chapter 13_Homocysteine in Nutritional Determinants; Genetic Susceptibility to Neural Tube Defect (NTD). -Chapter 14_Homocysteine metabolism dependent computational drug development: current status and future perspectives. -Chapter 15_Hyper-homocysteinemia mediated neuro-inflammation and neurodegenerative disorders. -Chapter 16_Homocysteinemia and viral infection (Covid-19).