Main description:

In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

Contents:

PART 1: ADAPTATION OF MICROBIAL METABOLISM IN HOST/PATHOGEN INTERACTION Metabolic adaptation of human pathogenic yersiniae Crosstalk between metabolism and virulence of Legionella pneumophila Metabolism of intracellular Salmonella enterica The human microbiome in health and disease Mechanisms of dysbiosis in the inflamed gut Strategies for microbial nutrient acquisition during infection of rice by Magnaporthe oryzae PART 2: NEW INHIBITORS AND TARGETS OF INFECTIOUS DISEASES Outer membrane proteins as potential anti-infective drug targets in Mannheimia haemolytica Identification of anti-infective compounds using amoebae Stress biology in fungi and "omic"-approaches as suitable tools analyzing plant-microbe interactions Targeting plasmids: new ways to plasmid curing Regulation of secondary metabolism in the grey mould fungus Botrytis cinerea