Main description:

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer's disease, Parkinson's disease, and Huntington's disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology.

Contents:

1. Neurodegenerative Diseases: Neuropathology, Genetics, and Epidemiology
2. Role of Caspases, Apoptosis and Additional Factors in Pathology of Alzheimer's disease
3. Role of Caspases and Apoptosis in Parkinson's disease
4. Illustrated Etiopathogenesis of Huntington's Disease