Main description:

Insulin: Deficiency, Excess and Resistance in Human Disease provides an overview of the role of insulin in the pathogenesis of prevalent non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer, along with a comprehensive review of insulin replacement therapies and novel cardioprotective and insulin-sensitizing drugs. Notable advances in precision diagnosis and therapy for single gene subtypes of diabetes in recent years are also discussed.

The discovery of insulin and its lifesaving introduction into clinical practice is one of the most celebrated accomplishments of medical science. However, despite decades of progress and major technical advances, the goal of providing insulin replacement therapy that truly mimics normal physiology remains elusive.

Contents:

Part 1. Normal physiology
1. Insulin synthesis and secretion
2. Metabolic regulation by insulin
3. Non-classic effects of insulin

Part 2. Disorders of Insulin Deficiency
4. Type 1 diabetes
5. Exogenous insulin replacement in type 1 diabetes
6. Pancreas and Islet transplantation
7. Treatment: artificial pancreas, immune modulation, stem cell therapy
8. Research methods in type 1 diabetes
9. Secondary forms of diabetes (type 4 diabetes)

Part 3. Syndromes of Insulin Excess
10. Congenital hyperinsulinism
11. Insulinoma and nesidioblastosis
12. Other causes of insulin excess

Part 4. Insulin Resistance in Human Disease
13. Etiopathogenesis of insulin resistance
14. Obesity and insulin resistance
15. Type 2 diabetes
16. The cardiometabolic syndrome
17. Insulin and cancer
18. Insulin and neurodegenerative diseases
19. Obesity management - nonpharmacological and pharmacological
20. Remission of type 2 diabetes via medical nutrition therapy
21. Bariatric surgery for obesity and related disorders
22. Pharmacotherapy for type 2 diabetes and associated cardiometabolic risk
23. Syndromes of severe insulin resistance
24. Research methods in obesity and type 2 diabetes
25. Future prospects for disorders of defective insulin physiology