Main description:

Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells.

Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression.

The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.

Contents:

Table of contents

1. Cancer immunoediting - elimination, equilibrium and immune escape in solid tumors
Jacek R. Wilczynski and Marek Nowak

2. Tumor - Stroma Interaction and Cancer
Michael P. Rogers, Zhiyong Mi, Neill Y. Li, Philip Y. Wai and Paul C. Kuo

3. Tumor-infiltrating lymphocytes and their role in solid tumor progression
Theresa L. Whiteside

4. Tumor-associated macrophages - reasons to be cheerful, reasons to be fearful
Izabela Szulc-Kielbik and Michal Kielbik

5. Polymorphonuclear neutrophils and tumors: friend or foe?
Izabela Szulc-Kielbik and Magdalena Klink

6. Role of NK cells in tumor progression
Inigo Terren and Francisco Borrego

7. The role of myeloid-derived suppressor cells in tumor growth and metastasis
Defne Bayik, Juyeun Lee and Justin D. Lathia

8. Cancer stem cells - an ever hiding foe
Jacek R. Wilczynski

9. Adoptive T-cell immunotherapy - Perfecting self-defenses
Raphaelle Toledano Zur, Galit Adler, Katerina Shamalov, Yair Tal, Chen Ankri and Cyrille J. Cohen

10. Monoclonal antibodies to CTLA-4 with focus on ipilimumab
Grazia Graziani, Lucia Lisi, Lucio Tentori and Pierluigi Navarra