Main description:

This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases.
This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to 'round out' the reader's journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.

Contents:

1. Organoids as a Model for Intestinal Ion Transport Physiology.- 2. Secretory Diarrhea.- 3. Role of the Epithelium in Diseases of the Intestine.- 4. Diseases of the Pancreas Involving Channels/Transporters.- 5. Fundamentals of Ion Transport across Human Sweat Gland in Health and Disease.- 6. Transporters in the Lactating Mammary Epithelium.- 7. Lipid Transport Across the Mammary Gland.- 8. Ion Transport across Inner Ear Epithelia.- 9. Regulation of Ion Transport through Retinal Pigment Epithelium: Impact in Retinal Degeneration.- 10. Ion Transport in the Choroid Plexus Epithelium.- 11. Transport Functions of Ectoderm Epithelial Cells Forming Dental Enamel.