Main description:

This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book.

Contents:

The Comparative Anatomy of Islets.- Microscopic Anatomy of the Human Islet of Langerhans.- Basement Membrane in Pancreatic Islet Function.- Approaches for Imaging Islets: Recent Advances and Future Prospects.- Mouse Islet Isolation.- Regulation of Pancreatic Islet Formation.- (Dys)Regulation of Insulin Secretion by Macronutrients.- Physiology and Pathology of the Anomeric Specificity for the Glucose-Induced Secretory Response of Insulin-, Glucagon-, and Somatostatin-Producing Pancreatic Islet Cells.- Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic Alpha-Cells.- Electrophysiology of Islet Cells.- ATP-Sensitive Potassium Channels in Health and Disease.- -cell Store-Operated Ion Channels.- Anionic Transporters and Channels in Pancreatic Islet Cells.- Chloride channels and Transporters in ss-cell physiology.- Electrical, Calcium, and Metabolic Oscillations in Pancreatic Islets.- Exocytosis in Islet -Cells.- Zinc Transporters in the pancreas.- High Fat Programming of -Cell Failure.- Exercise-Induced Pancreatic Islet Adaptations in Health and Disease.- Molecular basis of cAMP Signaling in pancreatic beta cells.- Calcium Signaling in the Islets.- Role of Mitochondria in -cell Function and Dysfunction.- IGF-1 and Insulin-Receptor Signalling in Insulin-Secreting Cells: From Function to Survival.- Circadian control of islet function.- Wnt Signaling in Pancreatic Islets.- Islet Structure and Function in the GK Rat.- -Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice].- Role of Reproductive Hormones in Islet Adaptation to Metabolic Stress.-
The -Cell in Human Type 2 Diabetes.- Pancreatic beta cells in metabolic syndrome.- Apoptosis in Pancreatic -Cells in Type 1 and Type 2 Diabetes.- Mechanisms of Pancreatic -Cell Apoptosis in Diabetes and Its Therapies.- Clinical Approaches to Preserve -Cell Function in Diabetes.- Role of NADPH Oxidase in Beta Cell Dysfunction.- The Contribution of Reg Family Proteins to Cell Growth and Survival in Pancreatic Islets.- Inflammatory Pathways Linked to Beta Cell Demise in Diabetes.- Immunology of -Cell Destruction.- Current Approaches and Future Prospects.- In Vivo Biomarkers for Detection of Beta Cell Death.- Proteomics and Islet Research.- Advances in Clinical Islet Isolation.- Islet Isolation from Pancreatitis Pancreas for Islet Autotransplantation.- Human Islet Autotransplantation.- Successes and Disappointments with Clinical Islet Transplantation.- Islet Xenotransplantation: An Update on Recent advances and Future Prospects.- Islet Encapsulation.- Stem Cells in Pancreatic Islets.- Generating Pancreatic Endocrine Cells from Pluripotent Stem Cells.- Pancreatic Neuroendocrine Tumors.

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