Main description:

Scientific progress with respect to the important role of various lipids in myocardial function and the dearrangements of lipid metabolism underlying ischaemic heart disease(s) has been con siderable in recent years. In 1986 alone, an overall number ofl 044 full papers covering the topics "Lipids-Heart-Heart Disease", have been published in a variety of biochemistry, physiology, pharmacology and cardiology journals (source: Index Medicus). They have broadened our in sight into the molecular basis of myocardial lipidology and the lipido-chemical basis of car diology in health and disease, and have narrowed the gap between promising pharmacological intervention in experimental animals and clinical treatment of patients suffering from an ischaemic heart. Furthermore, they illustrate the fundamental significance of the product of the union between basic and clinical science. The rapid development of knowledge in the "Lipids-Heart-Heart Disease" triad prompted us to organize the International Symposium on Lipid Metabolism in the Normoxic and lschaemic Heart, held in Rotterdam (The Netherlands) on September 22 and 23, 1986. This meeting was a coproject of the Department of Biochemistry I (Medical Faculty, Erasmus University Rotter dam) and the Department of Physiology (Medical Faculty, University of Limburg) and was held under the auspices of the GerritJan Mulder Foundation (named after a famous Rotterdam physi cian and chemist who lived from 1802-1880) whom we thank for their co-operation. The present volume is a compendium of invited papers and contributions selected from the posters presented during the symposium.

Contents:

Substrates for energy metabolism in the heart: the role of the interstitial compartment.- Uptake and transport of lipid substrates in the heart.- Synthesis, storage and degradation of myocardial triglycerides.- Stimulation of myocardial neutral triglyceride lipase activity by adenosine-3':5'monophosphate: involvement of glycogenolysis.- Triacylglycerol lipase activities in isolated myocardial cells from chronically diabetic rat hearts.- Lipoprotein lipase activity in ischaemic and anoxic myocardium.- Myocardial carnitine transport.- The role of the carnitine system in myocardial fatty acid oxidation: carnitine deficiency, failing mitochondria and cardiomyopathy.- The effect of exogenous L-carnitine on biochemical parameters in serum and in heart of the hyperlipidaemic rat.- Physico-chemical properties and organization of lipids in membranes: their possible role in myocardial injury.- Modulation of membrane protein function by bilayer lipids.- Serum factors which alter cell membranes.- Phospholipases of the myocardium.- Phospholipid alterations in canine cardiac sarcoplasmic reticulum induced by an acid-active phospholipase C.- Membrane phospholipid metabolism during myocardial ischaemia: past, present and future.- The effects of ischaemia, lysophosphatidylcholine and palmitoylcarnitine on rat heart phospholipase A2 activity.- Cholesterol and myocardial membrane function.- Lipid and carbohydrate metabolism in the ischaemic heart.- Metabolic disturbances during acute lack of oxygen: a short overview.- Accumulation of lipids and lipid-intermediates in the heart during ischaemia.- Free fatty acid metabolism in "stunned" myocardium.- Raised plasma non-esterified fatty acids (NEFA) during ischaemia: implications for arrhythmias.- Detrimental actions of endogenous fatty acids and their derivatives. A study of ischaemic mitochondrial injury.- Lysophospholipids, long chain acylcarnitines and membrane dysfunction in the ischaemic heart.- Dietary fatty acids and myocardial function.- The effects of dietary mackerel oil on the recovery of cardiac function after acute ischaemic events in the pig.- Eicosanoids and myocardial ischaemia.- Influence of intracellular Ca2+-overload in eicosanoid synthesis of the myocardium.- Lipid peroxidation and myocardial ischaemic damage: cause or consequence?.- Effects of free fatty acids, lysophosphatides and phospholipase treatment on lipid peroxidation of myocardial homogenates and membrane fractions.- Author Index.