Main description:

This authoritative book on MALDI MS, now finally available in its second edition and edited by one of its inventors, gives an in-depth description of the many different applications, along with a detailed discussion of the technology itself. Thoroughly updated and expanded, with contributions from key players in the field, this unique book provides a comprehensive overview of MALDI MS along with its possibilities and limitations. The initial chapters deal with the technology and the instrumental setup, followed by chapters on the use of MALDI MS in protein research (including proteomics), genomics, glycomics and lipidomics. The option of MALDI-MS for the analysis of polymers and small molecules are also covered in separate chapters, while new to this edition is a section devoted to the interplay of MALDI MS and bioinformatics. A much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.

Contents:

The MALDI Process and Method (Franz Hillenkamp, Thorsten Jaskolla, Michael Karas) MALDI Mass Spectrometry Instrumentation (Peter B. O'Connor, Klaus Dreisewerd, Kerstin Strupat, Franz Hillenkamp) MALDI-MS in Protein Chemistry and Proteomics (Karin Hjerno, Ole N. Jensen) MALDI Mass Spectrometry Imaging (Bernhard Spengler) Analysis of Nucleic Acids and Practical Implementations in Genomics and Genetics (Stefan Berkenkamp, Dirk van den Boom, Daniele Fabris) MALDI-MS of Glycans and Glycoconjugates (Helene Perreault, Erika Lattova, Dijana Sagi, Jasna Peter-Katalinic) Lipids (Jurgen Schiller, Beate Fuchs) MALDI-MS for Polymer Characterization (Liang Li) Small-Molecule Desorption/Ionization Mass Analysis (Lucinda H. Cohen, Fangbiao Li, Eden P. Go, Gary Siuzdak) Computational Analysis of High Throughput MALDI-TOF-MS Based Peptide Profiling (Thang V. Pham, Connie R. Jimenez) Biotyping of Microorganisms (Markus Kostrzewa)