Main description:

This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies.

Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics.

The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.

Contents:

Chapter 1. Introduction.- Chapter 1.1. Application of nanotechnology in biology and medicine.- Chapter 1.2. Biological activities of nanoparticles and mechanism of action.- Chapter 1.3. Application of nanoparticles in Drug delivery.- Chapter 1.4. Insecticidal activity nanoparticles and mechanism of action.- Chapter 2. Model organisms to understand biological activities of nanoparticles.- Chapter 2.1. Analysis of antimicrobial activity of metallic nanoparticles using prokaryotic model organisms.- Chapter 2.2. Analysis of antimicrobial activity of metallic nanoparticles using eukaryotic model organisms.- Chapter 2.2.1. Saccharomyces cerevisiae.- Chapter 2.2.2. Caenorhabditis elegans.- Chapter 2.2.3. Zebra fish model system.- Chapter 2.2.4. Drosophila melanogaster.- Chapter 2.2.5. Murine models.- Chapter 2.3. Investigation of biological activities of nanoparticles using cell lines.- Chapter 3. Model organisms to evaluate nanoparticle toxicity.- Chapter 3.1. Routes of Exposures and Toxicity of Nanoparticles.- Chapter 3.2. Toxicological evaluation of nanoparticles using prokaryotic model organisms.- Chapter 3.3. Toxicological evaluation of nanoparticles using eukaryotic model organisms.- Chapter 3.3.1. Saccharomyces cerevisiae.- Chapter 3.3.2. Caenorhabditis elegans.- Chapter 3.3.3. Zebra fish.- Chapter 3.3.4. Brine Shrimp.- Chapter 3.3.5. Drosophila melanogaster.- Chapter 3.3.6. Murine models.- Chapter 3.4. Evaluation of Toxicity Nanoparticles using Cell lines.- Chapter 3.5. Challenges and future perspectives of Nanotoxicology