Main description:

Volume 25, entitled Modern Avenues in Metal-Nucleic Acid Chemistry, of the series Metal Ions in Life Sciences (MILS), provides a timely overview of selected relevant developments in a field which previously had a pronounced focus on fundamental chemistry aspects such as coordination principles, structural chemistry, and consequences for biological processes and disease-related medicinal issues. More recently, also as a consequence of the advent of supramolecular chemistry, advancements in nanochemistry, and new bio-analytical methods, novel aspects of this field have emerged. MILS-25 gives a state-of-the-art account on the present state of research in this field, addressing, among others, porous materials, non-covalent interactions, stimuli-responsive bioconjugates, DNA-templated metal arrays and nanoclusters, genotyping, guanine quadruplexes, and riboswitches. It consists of 15 comprehensive chapters with over 1600 citations, 160 figures (90 of them in color), with key contributions from 40 international experts from Europe, Asia, and America. It is an essential resource for scientists from numerous disciplines, ranging from materials science to biochemistry, by way of classical chemistry and physics.

* It offers an update on nucleic acid - metal complex bioconjugates and their applications

* It provides an insight into coordination polymers involving nucleic acid components

* It covers a wide range of nucleic acids, from DNA duplexes, triplexes and quadruplexes to RNA

Contents:

Chapter 1 Porous Materials Built Up From Metal-Nucleobase Materials

Garikoitz Beobide, Oscar Castillo, Antonio Luque, and Sonia Perez-Yanez

Chapter 2 Cytosine and Its Derivatives as Useful Tools to Build Unusual and Fascinating Architectures

Teresa F. Mastropietro and Giovanni De Munno

Chapter 3 Coordination Polymers with Nucleobase Derivatives: From Electronic Nanodevices to Sensors

Noelia Maldonado and Pilar Amo-Ochoa

Chapter 4 Heavy Coinage Metal Nucleobase, Nucleoside and (Oligo)Nucleotide Systems: Recent Developments in Self-assembly, Opto-electronics, and DNA Integration

Andrew Houlton

Chapter 5 Interplay between Noncovalent Interactions and Metal Ions in Nucleic Acids and Their Constituents

Miquel Barcelo-Oliver, Antonio Frontera, Juan Jesus Fiol, Angel Garcia-Raso, and Angel Terron

Chapter 6 Biological Implications of Metal-Nucleobase Complexes

Saurabh Joshi, Ankita Jaiswal, Rajneesh Kumar Prajapati, and Sandeep Verma

Chapter 7 Stimuli-Responsive DNA-Binding Metal Complexes

Tim Kench and Ramon Vilar

Chapter 8 How Do Cationic Pt(II) Complexes Modify the Higher-Order Structure of DNA?

Seiji Komeda, Masako Uemura, Yuko Yoshikawa, and Kenichi Yoshikawa

Chapter 9 Metals in Genotyping: From SNPs to Sequencing

Tuomas Loennberg

Chapter 10 Nucleic Acids for the Preparation and Control of Continuous Hybrid Metallic Assemblies

Miguel A. Galindo, Fatima Linares, Alicia Dominguez-Martin, and Antonio Perez-Romero

Chapter 11 Recent Advances in the Development of Metal-Responsive Functional DNAs Based on Metal-Mediated Artificial Base Pairing

Yusuke Takezawa and Mitsuhiko Shionoya

Chapter 12 Nucleic Acid-Templated Metal Nanoclusters

Rweetuparna Guha and Stacy M. Copp

Chapter 13 G-Quadruplex Nucleic Acids and the Role of Metal Ions: Insights from Quantum Chemical Bonding Analyses

Celine Nieuwland and Celia Fonseca Guerra

Chapter 14 Transition Metal-Binding G-Quadruplex DNA

Lukas M. Stratmann and Guido H. Clever

Chapter 15 Metabolite Regulation by Riboswitches: The Role of Metal Ions in Folding, Ligand Binding, and Functionality

Maria Reichenbach, Sofia Gallo, and Roland K.O. Sigel

Index