Main description:

Aimed at advanced students as well as professionals and researchers, this advanced textbook provides a comprehensive overview of the current state of knowledge in the field of cellular aging. Starting out from the definition and description of an aged phenotype of selected tissues, the internationally recognized specialist authors discuss in detail the major molecular players in the aging process. * Covers both causative agents as well as regulatory circuits and signaling cascades known to affect senescence and their modulation by exogenous and endogenous factors.* Introduces biomarkers of aging and laboratory models for the investigation of aging processes.* Explores potential anti-aging approaches are extensively discussed.* Special features such as summary boxes and take-home messages in each chapter enhance the didactic value of this resource, while artwork is available to lecturers for download.

Contents:

Preliminary List of Contents: INTRODUCTION A Definition of Terms Hallmarks of Aging PLAYERS IN AGING Telomeres, Telomerase Reverse Transcriptase Mitochondria Insulin Signaling Further Signaling Processes Involved in Aging METHODS Age-Associated Biomarkers Aging-Related Biomarkers MODELS FOR THE STUDY OF AGING PROCESSES Yeast Caenorhabditis Elegans Drosophila Mouse Primates Mammalian Cell Culture Models ANTI-AGING APPROACHES: MEDICINE AND FOOD Overview on Anti-Aging Approaches ("The Good, The Bad and The Ugly")