Main description:

The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

Contents:

Natural products as enzyme inhibitors Natural ACE inhibitors with antihypertensive properties Hypoglycaemic effects of plants food constituents via inhibition of carbohydrate-hydrolysing enzymes: from chemistry to future applications. Natural Product Inhibitors of Cyclooxygenase (COX) Enzymes: Current Status and Future Perspective Natural Products Targeting Clinically Relevant Enzymes of Eicosanoid Biosynthesis implicated in inflammation and cancer Natural inhibitors of mitochondrial respiratory chain: therapeutic and toxicological implications Angiotensin-I-Converting enzyme (ACE-I) inhibitors from marine bio-resources Refreshing the Marine-derived Chemotherapeutic Pipeline Recent developments on the natural products and their derivatives targeting PfDHFR (Dihydrofolate reductase) and PfHSP (Heat sensitive protein) Phospholipase A2 inhibitors of marine origin: a target for inflammation Natural Plant-derived Acetylcholinesterase Inhibitors: Relevance for Alzheimer's disease Molecular Targets of Clinically-Relevant Natural Products from Filamentous Marine Cyanobacteria Natural inhibitors of beta-secretase Anti-HIV natural products