Main description:

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children. These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison s disease and Cushing syndrome, among others. Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed. This volume will become invaluable reading for paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians. Sections in the book cover * The GH-IGF1 axis and the brain * The thyroid axis and the brain * Regulation of appetite and weight * Effects of treatment of cancer on the neuroendocrine system * Adrenal disorders and the brain * Neuroendocrinology and the reproductive axis * Neurological complications of diabetes mellitus

Contents:

Section 1: The GH-IGF1 axis and the brain 1. Normal hypothalamo-pituitary function and the neuroendocrine regulation of growth, 2. Disorders of the GH-IGF1 axis leading to growth failure, 3. The effect of growth hormone on the brain 4. Impact of disorders of the GH-IGF1 axis on neurological functioning in childhood 5. Neuroencocrine Disorders of salt and water balance Section 2: The thyroid axis and the brain 6. The hypothalamic-pituitary-thyroid axis: anatomy and physiology 7. Disorders of the hypothalamo-pituitary-thyroid 8. Impact of Thyroid Disorders on Neurological Function Section 3: Regulation of appetite and weight 9. The role of the hypothalamus in normal weight regulation 10. Genetic childhood obesity syndromes 11. Treatment of Obesity Section 4: Effects of treatment of cancer on the neuroendocrine system 12. Late effects of cancer and its treatments on the neuroendocrine system, 13. Craniopharyngioma Section 5: Adrenal disorders and the brain 15. The hypothalamo-pituitary-adrenal axis and its regulation 16. The effect of stress on the hypothalamic-pituitary-adrenal axis: an update 17. Adrenoleukodystrophy- neurological aspects 18. Cushing disease: diagnosis and management Section 6: Neuroendocrinology and the reproductive axis 19. The hypothalamic-pituitary-gonadal axis 20. Disorders of gonadotrophin secretion Hypogonadotrophic hypogonadism 21 Precocious puberty 22. Psychological and behavioural consequences of gonadal hormone abnormality during early development Section 7 Neurological complications of diabetes mellitus 23. Diabetes and the developing brain 24. The Central actions of insulin