Main description:

This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations.The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral 'vectors' using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis.
This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.

Contents:

o Chapter 1. Dynamic interactive systems for constitutional water and ion nano-channelso Chapter 2. DNA transfection & Gene therapyo Chapter 3. Drug delivery : rotaxanes & polyrotaxanes, Smart polymeric materialso Chapter 4. New core-shell for active drug delivery : Magnetic nano-particles, CNTs, MOFso Chapter 5. Hydrogels for tissue engineering based on G-quartet, Chitosan & various monoaldehydeso Chapter 6. Tissue engineering o Chapter 7. Modelisation and computitional chemistry
-1) Simon Webb, University of Manchester, UK - Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers-2) Julien Boudon, Fadoua Sallem, Alexis Loiseau, Lionel Maurizi, Anne-Laure Papa, Nadine Millot, University of Bourgogne-Franche Conte, France - Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications-3) Christoph Janiak, University of Dusseldorf, Germany - Metal-organic Framework-Polymer Mixed-Matrix Membranes-4) Marc Baaden, Institut de Biologie Physico-Chimique, University of Paris, France - Insights into Adaptive Selforganized Supramolecular Structures from Molecular Modeling and Visualization
-5) Angela Casini, Technical University of Munich, German - Self-Assembled Metallacages as Drug Delivery Systems: Design Concepts and Challenge
-6) Alex Palma-Cando*, YachayTech University, Ecuador, and Ullrich Scherf, Bergische Universitat Wuppertal, Germany - Functional Microporous Polymer Networks: Synthesis and Applications-7) Claudiu T. Supuran*, University of Florence, Italy - A Story on Carbon Dioxide and its Hydration-8) Aatto Laaksonen, Stockholm University, Sweden - Inverse Design and Hierarchical Multiscale Modelling of Biological Matter-9) Kurt Vesterager Gothelf, iNANO, Aarhus University, Denmark - DNA-Directed Self-assembly of Macromolecular Structures
-10) Luisa De Cola, Institute de Science et d'Ingenierie Supramoleculaires (I.S.I.S.), University of Strasbourg, France and KIT, Germany - Luminescent Complexes and their Assemblies : from Understanding to Artificial Virus -11) Ulrich S. Schubert, Friedrich Schiller University Jena, Germany - Tailor-Made Polymers and Nanoparticles for Applications in Nanomedicine-12) Sinda Lepetre-Mouelhi, Institut Galien, University Paris-Saclay, France - Squalene-based Nanomedicines : An Original and Efficient Approach for the Treatment of Neurological Disorders without Crossing the Blood-Brain Barrier-13) Sylvia Wagner, Fraunhofer Institute for Biomedical Engineering IBMTSulzbach, Germany - Biodegradable Nanoparticles for Specific Drug Transport-14) Stephane P Vincent, University of Namur, Belgium - Multivalent rotaxanes designed as antibiofilm agents
SupraChem Lab, Iasi, RO-15) Mihaela Silion, Adina Coroaba, Radu Zonda, Sorin Ibanescu, Mariana Pinteala, Marc Abadie - Measuring Ionic Transport through Lipid Bilayers -16) Lilia Clima, Mariana Pinteala & Co - Polymeric Carriers for Transporting Nucleic Acids - Contributions to the Field-17) Gheorghe Fundueanu, Sanda Bucatariu, Marieta Constantin - Smart Polymeric Materials for Drug Delivery -18) Alexandru Rotaru, Laura Rusu, Mariana Pinteala & CO - Supramolecular Guanosine-quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications-19) Marin Luminita & CO - Hydrogelation of Chitosan with Monoaldehydes towards Biomaterials with Tuned Properties -20) Adrian Fifere, Mariana Pinteala & CO - Inorganic Nanoarticles as Free Radical Scavengers-21) Rosca Irina - A Microbiological Epilogue - Nosocomial Infections -22) Andrei Neamtu, Cornel Cojocaru - Molecular Dynamic Simulations and In Silico Analysis of Supramolecular Self-Assembled Structures-23) Dragos Peptanariu, Lilia Clima - Validation of the Non Toxicity of Non Viral Genetic-24) Adina Coroaba, Mariana Pinteala, Marc Abadie - Kinetics Transport of Ions/Water Through Nano-Scale Channels : Review And Update