Main description:

Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.

Contents:

Chapter One-- Assembly of Nuclear Pore Complex
Dr. Weidong Yang (Pennsylvania, USA) Email: weidong.yang@temple.edu
Chapter Two - Structure of Yeast Nuclear Pore Complexes
Dr. Jiong Ma (Shanghai, China), Email: jiongma@fudan.edu.cn
Chapter Three - Dynamic structures of the nuclear pore complex and their roles in nucleo-cytoplasmic transportDr. Martin Goldberg (Durham, UK), Email: m.w.goldberg@durham.ac.uk
Chapter Four - Non-canonical roles of nuclear pore proteins
Dr. Katharine S. Ullman (Utah, USA), Email: katie.ullman@hci.utah.edu
Chapter Five- On the role of the channel nucleoporins in nuclear transportDr. Sozanne Solmaz (Binghamton, USA), Email: ssolmaz@binghamton.edu
Chapter Six - Structures of Importins and Exportins
Dr. Yuh Min Chook (UT Southwestern, USA), Email: yuhmin.chook@utsouthwestern.edu
Chapter Seven--Navigating the Nuclear Envelope: one or multiple transport mechanisms for integral membrane proteins?
Dr. Eric C. Schirmer (Edinburg, UK), Email: e.schirmer@ed.ac.uk

Chapter Eight--mRNA export and its dysregulation in disease
Katherine Borden (Montreal, Canada), Email: katherine.borden@umontreal.ca
Chapter Nine--Coarse-grained molecular dynamics of the natively-unfolded domain of the NPC
Dr. P. R. Onck (Groningen, The Netherlands), Email: p.r.onck@rug.nl

Chapter Ten---On the effects of leukemogenic nucleoporin fusion proteins on nucleocytoplasmic transport and gene expression
Dr. Birthe Fahrenkrog (Brussels, Belgium), Email: bfahrenk@ulb.ac.be

Chapter Eleven---Structure and Function of the Nuclear Pore Complex Revealed by Advanced Fluorescence Microscopy
Dr. Weidong Yang (Pennsylvania, USA) Email: weidong.yang@temple.edu